C₃₅H₃₉FN₄O₄

Base Information

• Chemical Name: C₃₅H₃₉FN₄O₄
• CAS No.: 1311411-88-7
• Molecular Formula: C₃₅H₃₉FN₄O₄
• Molecular Weight: 598.717
• Mol file: 1311411-88-7.mol

Synonyms:C₃₅H₃₉FN₄O₄

Chemical Property of C₃₅H₃₉FN₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₃₉FN₄O₄

There total 30 articles about C₃₅H₃₉FN₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C40H47FN4O6 (1311411-86-5) → C35H39FN4O4 (1311411-88-7)

Guidance literature:

C₄₀H₄₇FN₄O₆; With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 0.5h;

With sodium carbonate; In water; isopropyl alcohol;

Reference yield:

C17H22BrNO4 (1311410-90-8) → C35H39FN4O4 (1311411-88-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 °C

2.1: sodium hydroxide / water; methanol / 3 h / 20 °C

2.2: pH 2 - 3

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 50 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere

6.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium carbonate; triethylamine; HATU; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

[2-(4-bromo-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (949885-93-2) → C35H39FN4O4 (1311411-88-7)

Guidance literature:

Multi-step reaction with 10 steps

1.1: iodine; magnesium / tetrahydrofuran / 60 - 65 °C / Inert atmosphere

1.2: 3 - 20 °C

1.3: -5 °C

2.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetone / 1 h / 20 °C

3.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 7.33 h / 20 °C

4.1: sodium tri-sec-butylborohydride / tetrahydrofuran / 1.5 h / -65 - -35 °C / Inert atmosphere

4.2: 0 - 10 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 1.5 h / -78 °C

6.1: sodium hydroxide / water; methanol / 3 h / 20 °C

6.2: pH 2 - 3

7.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

8.2: 50 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere

10.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium periodate; ruthenium(III) chloride trihydrate; iodine; sodium tri-sec-butylborohydride; sodium carbonate; potassium hydrogencarbonate; magnesium; triethylamine; HATU; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

upstream raw materials:

o-fluorobenzyl bromide

2-monochlorophenol

4-bromophenethanol

8-chloro-2,3-dihydro-4H-1-benzopyran-4-one

Downstream raw materials:

C₄₃H₅₂FN₅O₇

Refernces

• 1、 -. "5-AMINO- 4-HYDROXYPENTOYL AMIDES". . . Retrieved 2011/06/26.