bromo-2 butyl-4 pyridine

Base Information

• Chemical Name: bromo-2 butyl-4 pyridine
• CAS No.: 100933-54-8
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.105
• Mol file: 100933-54-8.mol

Synonyms:bromo-2 butyl-4 pyridine

Chemical Property of bromo-2 butyl-4 pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of bromo-2 butyl-4 pyridine

There total 1 articles about bromo-2 butyl-4 pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dibromopyridine (13534-89-9) + n-butyllithium (109-72-8,29786-93-4) → 2-bromo-pyridine (109-04-6) + bromo-2 deuterio-3 pyridine (54267-61-7) + bromo-2 butyl-4 pyridine (100933-54-8) + dibromo-2,4 deuterio-3 pyridine (100921-65-1)

Guidance literature:

With ethyl [2]alcohol; Product distribution; Mechanism; 1) THF, -40 deg C, 10 min, 2) THF, -40 deg C, 15 min; a new "homotransmetalation" reaction, further reagents and conditions;

DOI:10.1016/S0040-4020(01)96696-7

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + bromo-2 butyl-4 pyridine (100933-54-8) → 4-butyl-pyridine-2-carboxylic acid (83282-39-7)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) Et₂O, hexane, from -60 deg C to 40 deg C, 15 min, 2.) Et₂O, hexane, -60 deg C, 2 h;

DOI:10.1021/jm00368a020

Reference yield:

bromo-2 butyl-4 pyridine (100933-54-8) → N-[1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-4-guanidinomethyl-benzamide

Guidance literature:

Multi-step reaction with 7 steps

1: n-butyllithium / -78 °C

3: hydrogen / palladium on activated charcoal

4: sodium periodate / tetrahydrofuran

5: dicyclohexyl-carbodiimide

6: trifluoroacetic acid

With sodium periodate; n-butyllithium; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1: Metallation / 1: Acylation / 2: Condensation / 3: Catalytic hydrogenation / 4: N-dealkylation / 5: Acylation / 6: acidolysis / 7: Condensation;

DOI:10.1016/S0960-894X(00)00482-0

upstream raw materials:

2,3-dibromopyridine

n-butyllithium

Downstream raw materials:

4-butyl-pyridine-2-carboxylic acid

5-Amino-pentanoic acid [(S)-1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-amide

4-aminomethyl-N-[1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-benzamide

Refernces