2-iodomandelic acid

Base Information

• Chemical Name: 2-iodomandelic acid
• CAS No.: 89942-35-8
• Molecular Formula: C₈H₇IO₃
• Molecular Weight: 278.046
• Mol file: 89942-35-8.mol

Synonyms:2-iodomandelic acid

Chemical Property of 2-iodomandelic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-iodomandelic acid

There total 4 articles about 2-iodomandelic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2,2?dibromo?1?(2'?iodophenyl)ethan?1?one → 2-iodomandelic acid (89942-35-8)

Guidance literature:

With potassium hydroxide; In water; at 20 - 90 ℃; for 49h;

DOI:10.1007/s11696-018-0568-6

Reference yield:

2-iodoacetophenone (2142-70-3) → 2-iodomandelic acid (89942-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 0.17 h

2: potassium hydroxide / water / 49 h / 20 - 90 °C

With bromine; acetic acid; potassium hydroxide; In water;

DOI:10.1007/s11696-018-0568-6

Reference yield:

2-hydroxy-2-(2-iodophenyl)acetonitrile (118162-17-7) → 2-iodomandelic acid (89942-35-8)

Guidance literature:

With hydrogenchloride; water; for 2h; Reflux;

DOI:10.1021/je500845d

upstream raw materials:

2-hydroxy-2-(2-iodophenyl)acetonitrile

2-iodoacetophenone

Refernces

• 1、 Von Langermann, Jan,Temmel, Erik,Seidel-Morgenstern, Andreas,Lorenz, Heike. "Solid phase behavior in the chiral systems of various 2-hydroxy-2-phenylacetic acid (mandelic acid) derivatives". . p. 721 - 728. Retrieved 2015/03/30.