Technology Process of S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid trifluoroacetic acid salt
There total 9 articles about S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid trifluoroacetic acid salt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt;
With
hydrogenchloride; water;
In
1,4-dioxane;
at 60 ℃;
trifluoroacetic acid;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: hexane; acetone / 0.17 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
2.2: 0 - 20 °C
3.1: lithium hydroxide / water; methanol / 1.67 h / 20 °C
3.2: 0.17 h
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 20 °C
5.1: 0.25 h / 20 °C
6.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr
7.1: thionyl chloride / 0.25 h / 70 °C
8.1: pyridine / dichloromethane / 0.75 h / 20 °C
9.1: hydrogenchloride; water / 1,4-dioxane / 60 °C
With
pyridine; hydrogenchloride; thionyl chloride; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; hexane; dichloromethane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
1.2: 0 - 20 °C
2.1: lithium hydroxide / water; methanol / 1.67 h / 20 °C
2.2: 0.17 h
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 20 °C
4.1: 0.25 h / 20 °C
5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr
6.1: thionyl chloride / 0.25 h / 70 °C
7.1: pyridine / dichloromethane / 0.75 h / 20 °C
8.1: hydrogenchloride; water / 1,4-dioxane / 60 °C
With
pyridine; hydrogenchloride; thionyl chloride; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water;