1,2-bis(4-ethoxyphenyl)ethyne

Base Information

• Chemical Name: 1,2-bis(4-ethoxyphenyl)ethyne
• CAS No.: 2132-63-0
• Molecular Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.34
• Mol file: 2132-63-0.mol

Synonyms:1,2-bis(4-ethoxyphenyl)ethyne

Chemical Property of 1,2-bis(4-ethoxyphenyl)ethyne

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 1,2-bis(4-ethoxyphenyl)ethyne

There total 10 articles about 1,2-bis(4-ethoxyphenyl)ethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

calcium carbide (75-20-7) + 4-ethoxyphenylphenyldiazonium tetrafluoroborate (3108-14-3) → 1,2-bis(4-ethoxyphenyl)ethyne (2132-63-0)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium iodide; at 50 ℃; for 5h;

DOI:10.1055/s-0040-1706638

Reference yield:

1-ethoxy-4-iodobenzene (699-08-1) + 4-ethoxyphenylacetylene (79887-14-2) → 1,2-bis(4-ethoxyphenyl)ethyne (2132-63-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 81 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03164

Reference yield:

2,2-Dichloro-1,1-bis(4-ethoxyphenyl)ethylene (2132-71-0) → 1,2-bis(4-ethoxyphenyl)ethyne (2132-63-0) + 2,2-bis(4-ethoxyphenyl)acetic acid (20797-54-0)

Guidance literature:

With sodium ethanolate; at 180 ℃; im geschlossenen Rohr;

DOI:10.1359/jbmr.2001.16.2.398

upstream raw materials:

1,1-bis-(4-ethoxy-phenyl)-2-chloro-ethene

sodium ethanolate

1,1-bis-(4-ethoxy-phenyl)-2-bromo-ethene

1,1-bis(4-ethoxyphenyl)-2,2,2-trichloroethane

Downstream raw materials:

4,4'-diethoxy-deoxybenzoin

2,3-bis(4-ethoxyphenyl)-1H-inden-1-one

Refernces

• 1、 Li, Dejun,Zeng, Fanlong. "Palladium-Catalyzed Domino Alkenylation/Amination/Pyridination Reactions of 2-Vinylanilines with Alkynes: Access to Cyclopentaquinolines". supporting information. p. 6498 - 6501. Retrieved 2017/12/26.