2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride

Base Information

• Chemical Name: 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride
• CAS No.: 116989-51-6
• Molecular Formula: C₅H₈N₄O₂*ClH
• Molecular Weight: 192.605
• Mol file: 116989-51-6.mol

Synonyms:2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride

Chemical Property of 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride

There total 3 articles about 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-[2-(2-nitro-1H-imidazolyl)ethyl]phthalimide (100579-78-0) → 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride (116989-51-6)

Guidance literature:

With hydrogenchloride; In methanol; at 25 ℃; Inert atmosphere;

DOI:10.2174/15701786113106660087

Reference yield: 84.0%

tert-butyl 2-(2-nitro-1H-imidazol-1-yl)ethylcarbamate (1300727-12-1) → 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride (116989-51-6)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 5h;

DOI:10.1021/jm100545a

Reference yield:

(2-(2-nitro-1H-imidazol-1-yl)ethan-1-amine) (36717-77-8) → 2-(2-nitro-1H-imidazolyl)ethylamine hydrochloride (116989-51-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1039/c3cc38980d

upstream raw materials:

tert-butyl 2-(2-nitro-1H-imidazol-1-yl)ethylcarbamate

N-[2-(2-nitro-1H-imidazolyl)ethyl]phthalimide

(2-(2-nitro-1H-imidazol-1-yl)ethan-1-amine)

Downstream raw materials:

SCN-NOTA-2-NI-N-ethylamine

C₃₉H₄₇N₆O₂⁽¹⁺⁾*I^(1-)

1-[2-(2-nitro-1H-1-imidazolyl)ethyl]-3-iodobenzamide

2-(2-nitroimidazolyl)ethylamine-SCN-Bz-DOTA

Refernces

• 1、 Mei, Lei,Wang, Yue,Chu, Taiwei. "99mTc/Re complexes bearing bisnitroimidazole or mononitroimidazole as potential bioreductive markers for tumor: Synthesis, physicochemical characterization and biological evaluation". . p. 50 - 63. Retrieved 2012.
• 2、 Xu, Kehua,Wang, Feng,Pan, Xiaohong,Liu, Renpu,Ma, Jing,Kong, Fanpeng,Tang, Bo. "High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor". . p. 2554 - 2556. Retrieved 2013/04/24.