Technology Process of 1-(4-amino-3-methoxybenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
There total 10 articles about 1-(4-amino-3-methoxybenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1.1: 85 percent / pyridine / 20 °C
2.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
3.1: t-BuOK / toluene / 0.5 h / Heating
3.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
4.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
5.1: 31 percent / Et3N / CH2Cl2 / 2 h / 20 °C
6.1: 83 percent / conc. HCl; H2 / PtO2 / acetic acid / 760 Torr
With
pyridine; hydrogenchloride; PPA; potassium tert-butylate; hydrogen; potassium carbonate; triethylamine;
platinum(IV) oxide;
In
dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
1.1: Tosylation / 2.1: Alkylation / 3.1: Cyclization / 3.2: Hydrolysis / 4.1: detosylation / 5.1: Acylation / 6.1: Hydrogenation;
DOI:10.1016/S0968-0896(99)00101-7
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 100 percent / K2CO3 / acetone / 0.5 h / Heating
2.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C
3.1: 85 percent / pyridine / 20 °C
4.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
5.1: t-BuOK / toluene / 0.5 h / Heating
5.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
6.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
7.1: 31 percent / Et3N / CH2Cl2 / 2 h / 20 °C
8.1: 83 percent / conc. HCl; H2 / PtO2 / acetic acid / 760 Torr
With
pyridine; hydrogenchloride; PPA; potassium tert-butylate; hydrogen; potassium carbonate; triethylamine; tin(ll) chloride;
platinum(IV) oxide;
In
ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
1.1: Esterification / 2.1: Reduction / 3.1: Tosylation / 4.1: Alkylation / 5.1: Cyclization / 5.2: Hydrolysis / 6.1: detosylation / 7.1: Acylation / 8.1: Hydrogenation;
DOI:10.1016/S0968-0896(99)00101-7