ethyl 2-(dibenzylamino)-2-oxoacetate

Base Information

• Chemical Name: ethyl 2-(dibenzylamino)-2-oxoacetate
• CAS No.: 80326-96-1
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.354
• Mol file: 80326-96-1.mol

Synonyms:ethyl 2-(dibenzylamino)-2-oxoacetate

Chemical Property of ethyl 2-(dibenzylamino)-2-oxoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(dibenzylamino)-2-oxoacetate

There total 5 articles about ethyl 2-(dibenzylamino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Ethyl oxalyl chloride (4755-77-5) + dibenzylamine (103-49-1) → ethyl 2-(dibenzylamino)-2-oxoacetate (80326-96-1)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo1017603

Reference yield: 93.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + dibenzylamine (103-49-1) → ethyl 2-(dibenzylamino)-2-oxoacetate (80326-96-1)

Guidance literature:

With palladium 10% on activated carbon; oxygen; tetra-(n-butyl)ammonium iodide; at 60 ℃; for 2h; under 5320.36 Torr; Autoclave;

DOI:10.1021/jo401038e

Reference yield:

N,N-dibenzylglycine ethyl ester (77385-90-1) → N-benzylbenzamide (1485-70-7) + ethyl 2-(dibenzylamino)-2-oxoacetate (80326-96-1) + ethyl N-[benzoyl(benzyl)amino]acetate (80326-97-2) + N-benzylidene benzylamine (780-25-6) + ethyl glyoxylate hydrate (64805-08-9) + dibenzylamine (103-49-1)

Guidance literature:

With chlorine dioxide; In acetonitrile; for 1h; Product distribution; different pH's;

DOI:10.1021/jo00344a029

upstream raw materials:

oxalic acid diethyl ester

dibenzylamine

N,N-dibenzylglycine ethyl ester

Ethyl oxalyl chloride

Downstream raw materials:

(CH₃)2CHCOCH₂COCON(CH₂C₆H₅)2

(CH₃)3CCOCH₂COCON(CH₂C₆H₅)2

C₆H₅COCH₂COCON(CH₂C₆H₅)2

C₂H₅COCH(CH₃)COCON(CH₂C₆H₅)2

Refernces

• 1、 Kondoh, Azusa,Ishikawa, Sho,Aoki, Takuma,Terada, Masahiro. "Synthesis of 2,3-allenylamides utilizing [1,2]-phospha-Brook rearrangement and their application to gold-catalyzed cycloisomerization providing 2-aminofuran derivatives". supporting information. p. 12513 - 12516. Retrieved 2016/10/24.
• 2、 Gadge, Sandip T.,Bhanage, Bhalchandra M.. "Pd/C-catalyzed synthesis of oxamates by oxidative cross double carbonylation of amines and alcohols under Co-catalyst, base, dehydrating agent, and ligand-free conditions". . p. 6793 - 6797. Retrieved 2013/07/26.