3-Hydroxy-2-naphthamide

Base Information

• Chemical Name: 3-Hydroxy-2-naphthamide
• CAS No.: 3665-51-8
• Molecular Formula: C11H9 N O2
• Molecular Weight: 187.198
• Hs Code.: 2924299090
• European Community (EC) Number: 222-926-6
• NSC Number: 37060
• UNII: I7M9NQ16EI
• DSSTox Substance ID: DTXSID8063123
• Nikkaji Number: J40.508F
• Wikidata: Q72480623
• Mol file: 3665-51-8.mol

Synonyms:3-Hydroxy-2-naphthamide;3665-51-8;3-Hydroxynaphthalene-2-carboxamide;2-Hydroxy-3-naphtoamide;2-Hydroxy-3-naphthamide;2-Hydroxy-3-naphthoamide;2-Naphthalenecarboxamide, 3-hydroxy-;3-hydroxy-2-naphthalenecarboxamide;2-Hydroxy-3-naphthalenecarboxamide;2-NAPHTHAMIDE, 3-HYDROXY-;EINECS 222-926-6;NSC 37060;BRN 1104926;I7M9NQ16EI;NSC-37060;4-10-00-01188 (Beilstein Handbook Reference);NSC37060;UNII-I7M9NQ16EI;Oprea1_641266;WLN: L66J CVZ DQ;SCHEMBL550901;DTXSID8063123;3-HYDROXY-2-NAPHTHOAMIDE;2-hydroxy-3-naphthoic acid amide;MFCD00082972;3-hydroxy-2-naphthamide, AldrichCPR;AKOS003613091;3-HYDROXY-2-NAPHTHALENECARBAMIDE;AS-12392;LS-95126;CS-0207345;FT-0747941;A823325;Z68590127;3-hydroxynaphthalene-2-carboxamide

Chemical Property of 3-Hydroxy-2-naphthamide

Chemical Property:

• Vapor Pressure: 7.16E-08mmHg at 25°C
• Melting Point: 211-216 ºC
• Refractive Index: 1.4900 (estimate)
• Boiling Point: 426.4°Cat760mmHg
• PKA: 7.96±0.40(Predicted)
• Flash Point: 211.7°C
• PSA: 63.32000
• Density: 1.33g/cm³
• LogP: 2.34460
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 187.063328530
• Heavy Atom Count: 14
• Complexity: 229

Purity/Quality:

99%, ^*data from raw suppliers

2-Hydroxy-3-naphtoamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)N)O

Technology Process of 3-Hydroxy-2-naphthamide

There total 15 articles about 3-Hydroxy-2-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-acetoxy-2-naphthoyl chloride (53855-64-4) → 3-hydroxy-2-naphthalenecarboxamide (3665-51-8)

Guidance literature:

With ammonium hydroxide; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jm9508752

Reference yield: 90.0%

3-Hydroxy-2-naphthoic acid (92-70-6) → 3-hydroxy-2-naphthalenecarboxamide (3665-51-8)

Guidance literature:

With phosphoric acid; urea; at 180 ℃; for 2h;

DOI:10.1016/bs.mie.2021.01.037

Reference yield: 77.0%

→ 3-hydroxy-2-naphthalenecarboxamide (3665-51-8)

Guidance literature:

upstream raw materials:

3-hydroxy-2-naphthonitrile

ethyl 3-hydroxy-2-naphthanoate

3-hydroxy-2-naphthoyl chloride

3-methoxy-[2]naphthoic acid amide

Downstream raw materials:

2-(4-nitro-phenyl)-2,3-dihydro-naphtho[2,3-e][1,3]oxazin-4-one

2-phenyl-2,3-dihydro-naphtho[2,3-e][1,3]oxazin-4-one

2-(4-bromo-phenyl)-2,3-dihydro-naphtho[2,3-e][1,3]oxazin-4-one

2-(3-methoxy-phenyl)-2,3-dihydro-naphtho[2,3-e][1,3]oxazin-4-one

Refernces

• 1、 Kim, Ye Eun,Kim, Dong Hwan,Choi, Ami,Jang, Seoul,Jeong, Kwiwan,Kim, Young-Mi,Nam, Tae-Gyu. "Bi-aryl analogues of salicylic acids: Design, synthesis and sar study to ameliorate endoplasmic reticulum stress". . p. 3593 - 3604. Retrieved 2021/08/30.
• 2、 Sun, Yongjie,Zhao, Qingyang,Wang, Heng,Yang, Tilong,Wen, Jialin,Zhang, Xumu. "Asymmetric Hydrogenation of Cationic Intermediates for the Synthesis of Chiral N,O-Acetals". supporting information. p. 11470 - 11477. Retrieved 2020/08/10.