N-(4-chlorophenyl)-2-methyl-benzamide

Base Information

• Chemical Name: N-(4-chlorophenyl)-2-methyl-benzamide
• CAS No.: 65492-63-9
• Molecular Formula: C14H12 Cl N O
• Molecular Weight: 245.708
• Hs Code.: 2924299090
• Mol file: 65492-63-9.mol

Synonyms:o-Toluanilide,4'-chloro- (7CI); NSC 26405

Chemical Property of N-(4-chlorophenyl)-2-methyl-benzamide

Chemical Property:

• Vapor Pressure: 0.000879mmHg at 25°C
• Melting Point: 133 °C
• Boiling Point: 304.4°C at 760 mmHg
• PKA: 12.66±0.70(Predicted)
• Flash Point: 137.9°C
• PSA: 29.10000
• Density: 1.25g/cm³
• LogP: 3.97370

Purity/Quality:

99% ^*data from raw suppliers

4'-CHLORO-O-TOLUANILIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-chlorophenyl)-2-methyl-benzamide

There total 10 articles about N-(4-chlorophenyl)-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-methylbenzotrifluoride (13630-19-8) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-2-methylbenzamide (65492-63-9)

Guidance literature:

With ytterbium(III) oxide; sodium hydrogencarbonate; In neat (no solvent); at 20 ℃; for 1.5h; Milling;

DOI:10.1002/adsc.202100538

Reference yield: 82.0%

2-methylbenzotrifluoride (13630-19-8) + 4-chlorobenzonitrile (100-00-5) → N-(4-chlorophenyl)-2-methylbenzamide (65492-63-9)

Guidance literature:

With ytterbium(III) oxide; sodium hydrogencarbonate; silicon; In neat (no solvent); at 20 ℃; for 1.5h; Milling;

DOI:10.1002/adsc.202100538

Reference yield: 74.0%

2-methyl-benzyl alcohol (89-95-2) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-2-methylbenzamide (65492-63-9)

Guidance literature:

With tert.-butylhydroperoxide; C₅H₈AgClN₂O₄S₂; In ethanol; water; at 60 ℃; for 17h;

DOI:10.1016/j.tetlet.2019.02.024

upstream raw materials:

2-methyl-N-phenylbenzamide

ortho-methylbenzoic acid

4-chloro-aniline

ortho-toluoyl chloride

Downstream raw materials:

6-chloro-2-(2-methylphenyl)benzoxazole

6-chloro-2-(2-methylphenyl)-1,3-benzothiazole

C₁₄H₁₂ClNS

2-(4-chlorophenyl)-2,3-dihydro-1H-isoindol-1-one

Refernces

• 1、 Mkrtchyan, Satenik,Jakubczyk, Micha?,Lanka, Suneel,Yar, Muhammad,Ayub, Khurshid,Shkoor, Mohanad,Pittelkow, Michael,Iaroshenko, Viktor O.. "Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases". supporting information. p. 5448 - 5460. Retrieved 2021/10/19.
• 2、 Wang, Shao-Peng,Cheung, Chi Wai,Ma, Jun-An. "Direct Amidation of Carboxylic Acids with Nitroarenes". . p. 13922 - 13934. Retrieved 2019/11/03.