Technology Process of pre-tenellin B
There total 24 articles about pre-tenellin B which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C28H29NO4;
With
boron tribromide;
In
dichloromethane;
at -78 ℃;
for 1h;
Inert atmosphere;
In
methanol; dichloromethane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1002/asia.201402466
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
optical yield given as %de;
Darkness;
DOI:10.1002/anie.201007671
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4-methyl-2-morpholinone; tetrapropylammonium perruthennate / dichloromethane / 1 h / 0 - 20 °C / Molecular sieve; Inert atmosphere
2: dichloromethane / 16 h / 35 °C / Inert atmosphere
3: diisobutylaluminium hydride / hexane; dichloromethane / 0.25 h / -78 °C / Inert atmosphere
4: manganese(IV) oxide / dichloromethane / 16 h / 20 °C / Inert atmosphere
5: lithium hydroxide monohydrate / tetrahydrofuran; water / 96 h / Inert atmosphere; Darkness
6: trifluoroacetic acid / dichloromethane / 20 °C / Darkness
With
4-methyl-2-morpholinone; manganese(IV) oxide; tetrapropylammonium perruthennate; lithium hydroxide monohydrate; diisobutylaluminium hydride; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; water;
2: Wittig reaction / 5: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/anie.201007671
