Isonicotinaldehyde, azine

Base Information

• Chemical Name: Isonicotinaldehyde, azine
• CAS No.: 6957-22-8
• Molecular Formula: C12H10 N4
• Molecular Weight: 210.238
• Hs Code.: 2933990090
• European Community (EC) Number: 230-145-7
• ChEMBL ID: CHEMBL3208921
• Mol file: 6957-22-8.mol

Synonyms:Isonicotinaldehyde, azine;6957-22-8;197644-96-5;4-Pyridinecarboxaldehyde,2-(4-pyridinylmethylene)hydrazone;(1E,2E)-1,2-Bis(pyridin-4-ylmethylene)hydrazine;1,2-Bis(pyridin-4-ylmethylene)hydrazine;Isonicotinaldehyde (4-pyridylmethylene)hydrazone;EINECS 230-145-7;(E)-1-pyridin-4-yl-N-[(E)-pyridin-4-ylmethylideneamino]methanimine;4-[(1E)-[(E)-2-[(pyridin-4-yl)methylidene]hydrazin-1-ylidene]methyl]pyridine;4-[(1E)-[(E)-2-(pyridin-4-ylmethylidene)hydrazin-1-ylidene]methyl]pyridine;4-Pyridinecarboxaldehyde, (4-pyridinylmethylene)hydrazone;4-{[2-(pyridin-4-ylmethylidene)hydrazin-1-ylidene]methyl}pyridine;MLS001241038;SCHEMBL9966011;CHEMBL3208921;XLLIUDMGQNPRJS-KAVGSWPWSA-N;NSC 66165;AKOS015994020;HF-0025;NCGC00247378-01;AS-81882;SMR000841156;CS-0170044;CS-0379172;Z204610866;1-pyridin-4-yl-N-(pyridin-4-ylmethylideneamino)methanimine;Isonicotinaldehyde [(E)-4-pyridinylmethylidene]hydrazone #

Chemical Property of Isonicotinaldehyde, azine

Chemical Property:

• Vapor Pressure: 3.97E-05mmHg at 25°C
• Melting Point: 178 °C
• Boiling Point: 362.7°C at 760 mmHg
• PKA: 4.68±0.50(Predicted)
• Flash Point: 173.1°C
• PSA: 50.50000
• Density: 1.12g/cm³
• LogP: 1.92960
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 210.090546336
• Heavy Atom Count: 16
• Complexity: 211

Purity/Quality:

99%, ^*data from raw suppliers

1,2-Bis(pyridin-4-ylmethylene)hydrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1C=NN=CC2=CC=NC=C2
• Isomeric SMILES: C1=CN=CC=C1/C=N/N=C/C2=CC=NC=C2

Technology Process of Isonicotinaldehyde, azine

There total 9 articles about Isonicotinaldehyde, azine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

pyridine-4-carbaldehyde (872-85-5) → 4-pyridinealdazine (6957-22-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 0.333333h;

DOI:10.1039/c7dt03667a

Reference yield: 89.0%

Pyridine-4-carboxaldehyde hydrazone (51832-68-9) → (1E,2E)-1,2-bis(pyridin-4-ylmethylene)hydrazine (6957-22-8)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.0833333h;

DOI:10.1021/je00031a035

Reference yield: 75.0%

pyridine-4-carbaldehyde (872-85-5) → (1E,2E)-1,2-bis(pyridin-4-ylmethylene)hydrazine (6957-22-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.333333h;

DOI:10.1039/b500698h

upstream raw materials:

pyridine-4-carbaldehyde

Pyridine-4-carboxaldehyde hydrazone

N′-(pyridin-4-yl-benzylidene)-4-methylbenzenesulfonohydrazide

N'-[1-Pyridin-4-yl-meth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester

Refernces

• 1、 Kole, Goutam Kumar,Tan, Geok Kheng,Koh, Lip Lin,Vittal, Jagadese J.. "Co-crystals of tetrakis-1,2,3,4-(4′-carboxyphenyl)cyclobutane with dipyridyl spacers: Design and serendipity". . p. 6190 - 6195,6. Retrieved 2012.
• 2、 Zahedi, Mansoureh,Shaabani, Behrouz,Aygün, Muhittin,Kazak, Canan. "Construction of one dimensional Co(II) and Zn(II) coordination polymers based on expanded N,N′-donor ligands". . p. 461 - 468. Retrieved 2018.
• 3、 Chen, Wenjing,Jiang, Yanhong,Ding, Xuesong,Yan, Chaoguo,Han, Baohang. "Synthesis of Highly Stable Porous Metal-Iminodiacetic Acid Gels from A Novel IDA Compound". . p. 617 - 623. Retrieved 2016.
• 4、 Farahani, Yeganeh Davoudabadi,Safarifard, Vahid. "A luminescent metal-organic framework with pre-designed functionalized ligands as an efficient fluorescence sensing for Fe3+ ions". . p. 428 - 435. Retrieved 2019.
• 5、 Shi, Jian,Zhou, Yi,Wang, Keren,Ma, Qinge,Wei, Rongrui,Li, Qingfeng,Zhao, Yiyang,Qiao, Zhanpin,Liu, Shuang,Leng, Yumin,Liu, Wenmin,Sang, Zhipei. "Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease". . p. 624 - 634. Retrieved 2020/11/30.