2,4:3,5-DI-O-METHYLENE-D-IDARIC ACID

Base Information

• Chemical Name: 2,4:3,5-DI-O-METHYLENE-D-IDARIC ACID
• CAS No.: 7595-91-7
• Molecular Formula: C₁₀H₁₄O₈
• Molecular Weight: 262.216
• Mol file: 7595-91-7.mol

Synonyms:NSC403959

Chemical Property of 2,4:3,5-DI-O-METHYLENE-D-IDARIC ACID

Chemical Property:

• Vapor Pressure: 0.000304mmHg at 25°C
• Melting Point: >225°C (dec.)
• Boiling Point: 321.1°Cat760mmHg
• Flash Point: 140°C
• PSA: 89.52000
• Density: 1.325g/cm³
• LogP: -1.18460
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol, Water

Purity/Quality:

99%min ^*data from raw suppliers

2,4:3,5-Di-O-methylene-D-idaric Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4:3,5-Di-O-methylene-D-idaric Acid (cas# 7595-91-7 ) is a compound useful in organic synthesis.

Technology Process of 2,4:3,5-DI-O-METHYLENE-D-IDARIC ACID

There total 11 articles about 2,4:3,5-DI-O-METHYLENE-D-IDARIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 2,4:3,5-di-O-methylene-L-idaric acid (7437-68-5,7437-69-6,109007-98-9) → (4S,4aR,8S,8aR)-Tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4,8-dicarboxylic acid dimethyl ester (7595-91-7)

Guidance literature:

With hydrogenchloride; Heating;

Reference yield:

O2,O4;O3,O5-dimethanediyl-D-glucaric acid (7437-68-5,7437-69-6,109007-98-9) → 2,4:3,5-Di-O-methylen-D-glucarsaeure-dimethylester (4539-77-9,7595-91-7,114006-01-8,114421-41-9)

Guidance literature:

With hydrogenchloride; methanol;

DOI:10.1021/ja01201a021 DOI:10.1039/jr9440000058

Reference yield:

2,4:3,5-dimethylene-D-gluconic acid (5323-77-3) → 2,4:3,5-Di-O-methylen-D-glucarsaeure-dimethylester (4539-77-9,7595-91-7,114006-01-8,114421-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous alkaline solution; potassium permanganate

2: hydrogen chloride; methanol

With hydrogenchloride; methanol; potassium permanganate; alkaline solution;

DOI:10.1021/ja01201a021

upstream raw materials:

O²,O⁴;O³,O⁵-dimethanediyl-D-mannaric acid

O²,O⁴;O³,O⁵-dimethanediyl-D-glucaric acid

D-Glucono-1,5-lactone

2,4:3,5-dimethylene-D-gluconic acid

Downstream raw materials:

saccharic acid 1,4-lactone

L-idaric acid

Refernces

• 1、 Herd, J. Kenneth,Mayberry, William R.,Snell, Robert L.. "SYNTHESIS OF L-IDARO-1,4-LACTONE, AN INHIBITOR OF α-L-IDOSID-URONASE". . p. 33 - 40. Retrieved 2007/10/02.