Technology Process of C21H19F3N4O2
There total 5 articles about C21H19F3N4O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-methoxyquinoxalin-2-carboxylic acid;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
Inert atmosphere;
With
benzotriazol-1-ol;
In
tetrahydrofuran;
for 0.75h;
Inert atmosphere;
1-(3-Trifluoromethylphenyl)piperazine;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1002/ardp.201200038
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ethanol / 6.5 h / Reflux
2.1: N,N-dimethyl-formamide; trichlorophosphate / 0.5 h / Reflux
3.1: sodium carbonate / water; methanol / 6 h / Reflux
4.1: sodium methylate / 0.1 h / Reflux; Microwave irradiation
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
5.2: 0.75 h / Inert atmosphere
5.3: 6 h / 20 °C / Inert atmosphere
With
sodium methylate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; water;
DOI:10.1002/ardp.201200038
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N,N-dimethyl-formamide; trichlorophosphate / 0.5 h / Reflux
2.1: sodium carbonate / water; methanol / 6 h / Reflux
3.1: sodium methylate / 0.1 h / Reflux; Microwave irradiation
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
4.2: 0.75 h / Inert atmosphere
4.3: 6 h / 20 °C / Inert atmosphere
With
sodium methylate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; trichlorophosphate;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/ardp.201200038