2-(4-Chlorophenyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-1,3-dioxolane
• CAS No.: 2403-54-5
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 2932999099
• NSC Number: 202824
• DSSTox Substance ID: DTXSID60308251
• Nikkaji Number: J145.049B
• Wikidata: Q72456774
• Mol file: 2403-54-5.mol

Synonyms:2-(4-Chlorophenyl)-1,3-dioxolane;2403-54-5;1,3-Dioxolane,2-(4-chlorophenyl)-;1,3-Dioxolane, 2-(p-chlorophenyl)-;NSC 202824;1,3-Dioxolane, 2-(4-chlorophenyl)-;NSC202824;Clc1ccc(cc1)C2OCCO2;SCHEMBL6809631;2-p-Chlorophenyl-1,3-dioxolane;AMY3910;DTXSID60308251;2-(p-Chlorophenyl)-1,3-dioxolane;MFCD01823188;AKOS006279050;NSC-202824;2-(4-Chloro-phenyl)-[1,3]dioxolane;2-(4-Chlorophenyl)-1,3-dioxolane #

Chemical Property of 2-(4-Chlorophenyl)-1,3-dioxolane

Chemical Property:

• Appearance/Colour: Colorless transparent liquid
• Vapor Pressure: 0.0132mmHg at 25°C
• Refractive Index: 1.543
• Boiling Point: 267.8 °C at 760 mmHg
• Flash Point: 112.6 °C
• PSA: 18.46000
• Density: 1.256 g/cm³
• LogP: 2.38540
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 138

Purity/Quality:

99.9% ^*data from raw suppliers

2-(4-CHLOROPHENYL)-1,3-DIOXOLANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)C2=CC=C(C=C2)Cl

Technology Process of 2-(4-Chlorophenyl)-1,3-dioxolane

There total 10 articles about 2-(4-Chlorophenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

4-chlorobenzaldehyde (104-88-1) + ethylene glycol (107-21-1) → 2-(4-chlorophenyl)-1,3-dioxolane (2403-54-5)

Guidance literature:

silica gel; In n-heptane; for 24h; Heating;

DOI:10.1016/S0040-4039(00)94946-3

Reference yield: 95.0%

2-(4-chlorophenyl)-1,3-oxathiolane (22391-05-5) + ethylene glycol (107-21-1) → 2-(4-chlorophenyl)-1,3-dioxolane (2403-54-5)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1016/S0040-4020(02)00389-7

Reference yield: 95.0%

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane (7381-30-8) + 4-chlorobenzaldehyde (104-88-1) → 2-(4-chlorophenyl)-1,3-dioxolane (2403-54-5)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; at 20 ℃; for 1.66667h;

DOI:10.1055/s-0030-1258148

upstream raw materials:

4-chlorobenzaldehyde

ethylene glycol

ethoxyethoxyethanol

(4-chlorophenyl)chlorodiazirine

Downstream raw materials:

4-chlorobenzaldehyde

1-chloro-4-{[(phenylmethyl)oxy]methyl}benzene

2-<4-(1-hydroxycyclohexyl)phenyl>-1,3-dioxolane

2-(4-chlorophenyl)-1,3-dithiolane

Refernces

• 1、 Shi, Yingxia,Liang, Xuezheng. "Robust acidic pseudo-ionic liquid catalyst with self-separation ability for esterification and acetalization". . p. 1413 - 1421. Retrieved 2019/05/04.
• 2、 Pomeisl, Karel,Pohl, Radek,Snoeck, Robert,Andrei, Graciela,Kre?merová, Marcela. "Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity". . p. 119 - 156. Retrieved 2019/01/04.