N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide

Base Information

• Chemical Name: N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide
• CAS No.: 1574347-89-9
• Molecular Formula: C₂₄H₄₉NO₃S
• Molecular Weight: 431.724
• Mol file: 1574347-89-9.mol

Synonyms:N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide

Chemical Property of N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide

There total 3 articles about N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-[(1R,2R)-2-(benzyloxy)cyclohexyl]octadecane-1-sulphonamide (1574347-88-8) → N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide (1574347-89-9)

Guidance literature:

With Pd(OH)2/C; acetic acid; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3ob42164c

Reference yield:

(1R,2R)-2-(benzyloxy)cyclohexan-1-amine (216394-07-9,216394-06-8) → N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide (1574347-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C / Inert atmosphere

2: Pd(OH)2/C; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With Pd(OH)2/C; acetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3ob42164c

Reference yield:

1-octadecanesulfonyl chloride (10147-41-8) → N-[(1R,2R)-2-hydroxycyclohexyl]octadecane-1-sulphonamide (1574347-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C / Inert atmosphere

2: Pd(OH)2/C; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With Pd(OH)2/C; acetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3ob42164c

upstream raw materials:

N-[(1R,2R)-2-(benzyloxy)cyclohexyl]octadecane-1-sulphonamide

(1R,2R)-2-(benzyloxy)cyclohexan-1-amine

1-octadecanesulfonyl chloride

Refernces