Technology Process of 4-methylbenzaldehyde (E)-O-[(1S)-2-hydroxy-1-phenylethyl]oxime
There total 23 articles about 4-methylbenzaldehyde (E)-O-[(1S)-2-hydroxy-1-phenylethyl]oxime which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
toluene;
for 0.5h;
Heating;
DOI:10.1021/jo049517+
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / NaBH4 / methanol / 0.5 h / 20 °C
2: 81 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 48 h / 20 °C
3: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating
4: 99 percent / TsOH / toluene / 0.5 h / Heating
With
sodium tetrahydroborate; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; ethanol; toluene;
2: Mitsunobu reaction;
DOI:10.1021/jo049517+
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 99 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
2.1: 99 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 9 h / 20 °C
3.1: conc. HCl / methanol / 0.5 h / 20 °C
3.2: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating
4.1: 99 percent / TsOH / toluene / 0.5 h / Heating
5.1: 60 percent / toluene; diethyl ether / 0.42 h / -20 °C
6.1: Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C
7.1: 81 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 48 h / 20 °C
8.1: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating
9.1: 99 percent / TsOH / toluene / 0.5 h / Heating
With
hydrogenchloride; lithium aluminium tetrahydride; hexacarbonyl molybdenum; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; toluene; acetonitrile;
2.1: Mitsunobu reaction / 7.1: Mitsunobu reaction;
DOI:10.1021/jo049517+
