Methanesulfonamide,N-(2-hydroxyphenyl)-

Base Information

• Chemical Name: Methanesulfonamide,N-(2-hydroxyphenyl)-
• CAS No.: 6912-38-5
• Molecular Formula: C7H9 N O3 S
• Molecular Weight: 187.219
• Hs Code.: 2935009090
• Mol file: 6912-38-5.mol

Synonyms:Methanesulfonanilide,2'-hydroxy- (6CI,7CI,8CI); 2-(Methylsulfonylamino)phenol;2'-Hydroxymethanesulfonanilide; NSC 245031; o-(Methanesulfonamido)phenol

Chemical Property of Methanesulfonamide,N-(2-hydroxyphenyl)-

Chemical Property:

• Vapor Pressure: 0.000147mmHg at 25°C
• Boiling Point: 322.6°C at 760 mmHg
• Flash Point: 148.9°C
• PSA: 74.78000
• Density: 1.458g/cm³
• LogP: 1.91750

Purity/Quality:

98% ^*data from raw suppliers

N-(2-hydroxyphenyl)methanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonamide,N-(2-hydroxyphenyl)-

There total 2 articles about Methanesulfonamide,N-(2-hydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methanesulfonyl chloride (124-63-0) + 2-amino-phenol (95-55-6) → N-(2-hydroxyphenyl)methanesulphonamide (6912-38-5)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 2h;

Reference yield:

→ N-(2-hydroxyphenyl)methanesulphonamide (6912-38-5)

Guidance literature:

Reference yield:

N-(2-hydroxyphenyl)methanesulphonamide (6912-38-5) → N-cyclohexylmethanesulfonamide (19299-40-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / Et₃N / benzene; acetonitrile / 20 h / 20 °C

2: 93 percent / PCl₅ / benzene; CCl₄ / 12 h / 20 °C

3: 99 percent / Et₃N / diethyl ether / 1 h / 20 °C

4: 97 percent / 1-methylimidazole / CH₂Cl₂ / 1 h

5: 73 percent / H₂, TFA, AcOH / PtO₂ / 20 h / 20 °C / 750.06 Torr

With 1-methyl-1H-imidazole; phosphorus pentachloride; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In tetrachloromethane; diethyl ether; dichloromethane; acetonitrile; benzene;

upstream raw materials:

methanesulfonyl chloride

2-amino-phenol

Downstream raw materials:

N-cyclohexylmethanesulfonamide

Diethyl 2-(methylsulfonylamino)phenyl phosphate

Ethyl isopropyl 2-(methylsulfonylamino)phenyl phosphate

5-methanesulfonyl-4,5-dihydro-benzo[b][1,4]oxazepin-3-one (toluene-4-sulfonyl)-hydrazone

Refernces

• 1、 -. "Use of 2-(sulphonylamino) phenols as couplers in oxidation colouring". . . Retrieved 2008/06/13.