9H-1,3,4,9-TETRAAZA-FLUORENE-2-THIOL

Base Information

• Chemical Name: 9H-1,3,4,9-TETRAAZA-FLUORENE-2-THIOL
• CAS No.: 28668-95-3
• Molecular Formula: C9H6 N4 S
• Molecular Weight: 202.239
• Hs Code.: 2933990090
• Mol file: 28668-95-3.mol

Synonyms:3H-1,2,4-Triazino[5,6-b]indole-3-thione,2,5-dihydro- (9CI); 5H-as-Triazino[5,6-b]indole-3-thiol (7CI,8CI); 2-Mercapto-1,3,4-triazacarbazole;4,5-Dihydro-1,2,4-triazino[5,6-b]indole-3-thione; NSC 75196

Chemical Property of 9H-1,3,4,9-TETRAAZA-FLUORENE-2-THIOL

Chemical Property:

• Vapor Pressure: 1.14E-06mmHg at 25°C
• Melting Point: >350 °C
• Boiling Point: 401.9°Cat760mmHg
• PKA: 9.60±0.20(Predicted)
• Flash Point: 196.9°C
• PSA: 89.45000
• Density: 1.69g/cm³
• LogP: 2.16870

Purity/Quality:

99% ^*data from raw suppliers

5H-[1,2,4]triazino[5,6-b]indole-3-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9H-1,3,4,9-TETRAAZA-FLUORENE-2-THIOL

There total 13 articles about 9H-1,3,4,9-TETRAAZA-FLUORENE-2-THIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + thiosemicarbazide (79-19-6) → 2,5-dihydro-3H-1,2,4-triazino[5,6-b]indole-3-thione (28668-95-3)

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 7h; Reflux;

DOI:10.3390/molecules18032683

Reference yield: 92.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + thiosemicarbazide (79-19-6) → 3-mercapto-5H-1,2,4-triazino[5,6-b]indole (28668-95-3)

Guidance literature:

With potassium carbonate; for 16h; Reflux;

Reference yield: 87.0%

indole-2,3-dione 3-thiosemicarbazone (1165809-20-0) → 3-mercapto-5H-1,2,4-triazino[5,6-b]indole (28668-95-3)

Guidance literature:

With potassium carbonate; microwave irradiation;

DOI:10.1055/s-2004-815437

upstream raw materials:

indole-2,3-dione 3-thiosemicarbazone

indole-2,3-dione

thiosemicarbazide

thiosemicarbazide hydrochloride

Downstream raw materials:

1-Phenyl-3-[2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-acetyl]-urea

ethyl ester of (1,2,4-triazino[5,6-b]indolyl-3-thio)acetic acid

2-Carboxymethylmercapto-1,3,4-triaza-carbazol

3-(prop-2-yn-1-ylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole

Refernces

• 1、 Arshad, Mohammad,Bhat, Abdul Roouf,Hoi, Kwon Kang,Choi, Inho,Athar, Fareeda. "Synthesis, characterization and antibacterial screening of some novel 1,2,4-triazine derivatives". . p. 1559 - 1565. Retrieved 2017.
• 2、 Gomha, Sobhi M.,Abdel-Aziz, Hatem A.. "Synthesis of new functionalized derivatives of 1,2,4-triazolo[4',3':2,3][1, 2,4]triazino[5,6-b]indole". . p. 1119 - 1125. Retrieved 2013.
• 3、 Rybakova,Kim,Ezhikova,Kodess,Taherc. "Synthesis of novel [1,3]thiazino[3,2:2,3][1,2,4]triazino[5,6-b]indole derivatives". . p. 901 - 904. Retrieved 2015.
• 4、 Khan, Aftab Ahmad,Rahim, Fazal,Taha, Muhammad,Rehman, Wajid,Iqbal, Naveed,Wadood, Abdul,Ahmad, Nisar,Shah, Syed Adnan Ali,Ghoneim, Mohammed M.,Alshehri, Sultan,Salahuddin, Mohammed,Khan, Khalid Mohammed. "New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study". . p. 77 - 85. Retrieved 2022/02/07.
• 5、 -. "Indole derivative and application thereof". Paragraph 0091-0093; 0124-0125. . Retrieved 2020/04/17.