C₅₁H₅₅N₂O₆P

Base Information

• Chemical Name: C₅₁H₅₅N₂O₆P
• CAS No.: 1394940-72-7
• Molecular Formula: C₅₁H₅₅N₂O₆P
• Molecular Weight: 822.981
• Mol file: 1394940-72-7.mol

Synonyms:C₅₁H₅₅N₂O₆P

Chemical Property of C₅₁H₅₅N₂O₆P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₁H₅₅N₂O₆P

There total 3 articles about C₅₁H₅₅N₂O₆P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-benzyl carbamate (621-84-1) + tris(4-(tert-butyl)phenyl) phosphite (4235-89-6) + 4-oxo-N-tritylbutanamide (159492-89-4) → C51H55N2O6P (1394940-72-7)

Guidance literature:

tri(p-tert-butylphenyl) phosphite; With trichlorophosphate; In acetonitrile; for 6h; Reflux;

O-benzyl carbamate; 4-oxo-N-tritylbutanamide; With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; for 4h; Reflux;

DOI:10.1016/j.bmcl.2012.07.011

Reference yield:

methyl 4-oxo-4-(tritylamino)butanoate (1195771-44-8) → C51H55N2O6P (1394940-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.25 h / -60 °C

3.1: trichlorophosphate / acetonitrile / 6 h / Reflux

3.2: 4 h / Reflux

With lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 2.1: Swern oxidation / 2.2: Swern oxidation;

DOI:10.1016/j.bmcl.2012.07.011

Reference yield:

4-hydroxy-N-tritylbutanamide (102560-84-9) → C51H55N2O6P (1394940-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.25 h / -60 °C

2.1: trichlorophosphate / acetonitrile / 6 h / Reflux

2.2: 4 h / Reflux

With oxalyl dichloride; dimethyl sulfoxide; trichlorophosphate; In dichloromethane; acetonitrile; 1.1: Swern oxidation / 1.2: Swern oxidation;

DOI:10.1016/j.bmcl.2012.07.011

upstream raw materials:

methyl 4-oxo-4-(tritylamino)butanoate

O-benzyl carbamate

tris(4-(tert-butyl)phenyl) phosphite

4-oxo-N-tritylbutanamide

Downstream raw materials:

C₄₃H₅₉N₄O₁₀P

C₃₂H₄₁N₂O₆P

C₄₃H₄₉N₂O₄P

C₅₇H₆₆N₃O₇P

Refernces