Technology Process of 5-methyl-4-phenyl-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester
There total 8 articles about 5-methyl-4-phenyl-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Pd/C / 200 °C
2.1: LiAlH4 / diethyl ether / 0.17 h / 20 °C
3.1: 8.56 g / p-TsOH*H2O / benzene / 0.5 h / 20 - 100 °C
4.1: aq. NaClO; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; 4-phenylpyridine N-oxide / 5 h / 20 °C
5.1: H2SO4; acetonitrile / hexane / 1 h / 20 °C
5.2: 52 percent / H2O / 2 h / 100 °C
6.1: CHCl3 / 3 h / 24 °C
With
sodium hypochlorite; lithium aluminium tetrahydride; 4-Phenylpyridine 1-oxide; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; sulfuric acid; toluene-4-sulfonic acid; acetonitrile;
palladium on activated charcoal;
In
diethyl ether; hexane; chloroform; benzene;
1.1: Diels-Alder reaction / 5.1: Jacobsen reaction / 6.1: Ritter reaction;
DOI:10.1021/jo049381f
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Pd/C / 200 °C
2.1: LiAlH4 / diethyl ether / 0.17 h / 20 °C
3.1: 8.56 g / p-TsOH*H2O / benzene / 0.5 h / 20 - 100 °C
4.1: aq. NaClO; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; 4-phenylpyridine N-oxide / 5 h / 20 °C
5.1: H2SO4; acetonitrile / hexane / 1 h / 20 °C
5.2: 52 percent / H2O / 2 h / 100 °C
6.1: CHCl3 / 3 h / 24 °C
With
sodium hypochlorite; lithium aluminium tetrahydride; 4-Phenylpyridine 1-oxide; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; sulfuric acid; toluene-4-sulfonic acid; acetonitrile;
palladium on activated charcoal;
In
diethyl ether; hexane; chloroform; benzene;
1.1: Diels-Alder reaction / 5.1: Jacobsen reaction / 6.1: Ritter reaction;
DOI:10.1021/jo049381f