3-fluoro-5-benzyloxycarbonylaminopyridine

Base Information

• Chemical Name: 3-fluoro-5-benzyloxycarbonylaminopyridine
• CAS No.: 247235-86-5
• Molecular Formula: C₁₃H₁₁FN₂O₂
• Molecular Weight: 246.241
• Mol file: 247235-86-5.mol

Synonyms:3-fluoro-5-benzyloxycarbonylaminopyridine

Chemical Property of 3-fluoro-5-benzyloxycarbonylaminopyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-5-benzyloxycarbonylaminopyridine

There total 1 articles about 3-fluoro-5-benzyloxycarbonylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5-fluoropyridine-3-carboxylic acid (402-66-4) + benzyl alcohol (100-51-6,185532-71-2) → 3-fluoro-5-benzyloxycarbonylaminopyridine (247235-86-5)

Guidance literature:

5-fluoropyridine-3-carboxylic acid; With 4-methyl-morpholine; diphenyl-phosphinic acid; In 1,2-dichloro-ethane; for 0.5h;

In 1,2-dichloro-ethane; at 75 ℃; for 1h;

benzyl alcohol; With copper(l) chloride; In 1,2-dichloro-ethane; for 3h; Heating;

DOI:10.1021/jm9901935

Reference yield: 97.0%

3-fluoro-5-benzyloxycarbonylaminopyridine (247235-86-5) → 5-fluoropyridin-3-amine (210169-05-4)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 1.5h; Heating;

DOI:10.1021/jm9901935

Reference yield:

3-fluoro-5-benzyloxycarbonylaminopyridine (247235-86-5) → (5-Fluoro-pyridin-3-yl)-[1-phenyl-meth-(E)-ylidene]-amine

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / ammonium formate / 10 percent Pd/C / methanol / 1.5 h / Heating

2: toluene / 3 h / Heating

With ammonium formate; palladium on activated charcoal; In methanol; toluene; 1: Hydrogenolysis / 2: Condensation;

DOI:10.1021/jm9901935

upstream raw materials:

5-fluoropyridine-3-carboxylic acid

benzyl alcohol

Downstream raw materials:

5-fluoropyridin-3-amine

benzyl-(5-fluoro-pyridin-3-yl)-amine

Refernces