biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

Base Information

• Chemical Name: biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester
• CAS No.: 743460-48-2
• Molecular Formula: C₂₁H₂₇N₃O₂
• Molecular Weight: 353.464
• Hs Code.: 2933998090
• Mol file: 743460-48-2.mol

Synonyms:biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

Chemical Property of biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

Chemical Property:

• Boiling Point: 477.2±45.0 °C(Predicted)
• Density: 1.16±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Biphenyl-2-ylcarbamic Acid 1-[2-(Methylamino)ethyl]piperidin-4-yl Ester Hydrochloride is a useful intermediate in the preparation of revefenacin and it’s salts.

Technology Process of biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester

There total 15 articles about biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C24H28Cl3N3O4 → biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester (743460-48-2)

Guidance literature:

With acetic acid; zinc; In tetrahydrofuran; at 30 ℃; for 4h; Solvent;

Reference yield: 86.0%

C36H37N3O4 → biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester (743460-48-2)

Guidance literature:

With morpholine; In tetrahydrofuran; at 30 ℃; for 4h; Solvent;

Reference yield: 70.0%

biphenyl-2-yl-carbamic acid 1-[2-(benzylmethylamino)ethyl]piperidin-4-yl ester (864686-28-2) → biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester (743460-48-2)

Guidance literature:

With hydrogen; acetic acid; palladium 10% on activated carbon; In ethanol; for 3h; under 3345.86 Torr;

upstream raw materials:

N-<(benzyloxy)carbonyl>-N-methylaminoacetaldehyde

1-benzyl-4-piperidylbiphenyl-2-ylcarbamate

biphenyl-2-ylcarbamic acid 1-[2-((benzyloxycarbonyl)-N-methylamino)ethyl]piperidin-4-yl ester

biphenyl-2-yl-carbamic acid 1-[2-(benzylmethylamino)ethyl]piperidin-4-yl ester

Downstream raw materials:

biphenyl-2-ylcarbamic Acid 1-{2-[(4-formylbenzenesulfonyl)methylamino]-ethyl}piperidin-4-yl ester

biphenyl-2-ylcarbamic acid 1-{2-[(6-tert-butoxycarbonylaminohexanoyl)-methylamino]ethyl}piperidin-4-yl ester

biphenyl-2-yl-carbamic acid 1-{2-[(4-formylbenzoyl)methylamino]ethyl}piperidin-4-yl ester

1-(2-{[(3-Formylphenyl)carbonyl](methyl)amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate

Refernces

• 1、 -. "Preparation method of revefenacin intermediate". Paragraph 0133; 0137; 0138; 0182-0194. . Retrieved 2021/07/17.
• 2、 Hughes, Adam D.,Chen, Yan,Hegde, Sharath S.,Jasper, Jeffrey R.,Jaw-Tsai, Sarah,Lee, Tae-Weon,McNamara, Alexander,Pulido-Rios, M. Teresa,Steinfeld, Tod,Mammen, Mathai. "Discovery of (R)-1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class dual pharmacology multivalent muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)". supporting information. p. 2609 - 2622. Retrieved 2015/04/14.