tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline

Base Information

• Chemical Name: tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline
• CAS No.: 125050-17-1
• Molecular Formula: C₁₇H₂₄BrNO₄
• Molecular Weight: 386.286
• Mol file: 125050-17-1.mol

Synonyms:tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline

Chemical Property of tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline

There total 15 articles about tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Benzyloxycarbonylamino-5-hydroxy-pentanoic acid tert-butyl ester (124620-51-5) → tert-butyl ester of α-N-carbobenzoxy-δ-bromonorvaline (125050-17-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran;

DOI:10.1021/jo00293a010

Reference yield: 81.0%

(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester (5891-45-2) → (S)-tert-butyl 2-(benzyloxycarbonylamino)-5-bromopentanoate (125050-17-1)

Guidance literature:

(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester; With N-methyl-2-indolinone; chloroformic acid ethyl ester;

With sodium tetrahydroborate; In methanol;

With carbon tetrabromide; triphenylphosphine;

DOI:10.1016/S0040-4039(03)01222-X

Reference yield:

(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-5-hydroxypentanoate (124620-51-5) → (S)-tert-butyl 2-(benzyloxycarbonylamino)-5-bromopentanoate (125050-17-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 0.05h; Ambient temperature;

DOI:10.1246/cl.1996.621

upstream raw materials:

2-Benzyloxycarbonylamino-5-hydroxy-pentanoic acid tert-butyl ester

L-t-butyl pyroglutamate

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate

N-benzoyloxycarbonyl L-glutamic acid α-t-butylester

Downstream raw materials:

N-(benzyloxy)amide of α-N-carbobenzoxy-δ-bromo-D-norvaline

tert-butyl 5-(4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-piperidin-1-yl)-N-(benzyloxycarbonyl)-L-norvalinate

tert-butyl 5-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-N-(benzyloxycarbonyl)-L-norvalinate

(S)-2-tert-butyl-1-benzylpyrrolidine-1,2-dicarboxylate

Refernces

• 1、 -. "PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER". Page/Page column 30. . Retrieved 2008/12/05.
• 2、 -. "INHIBITORS OF P38 MAP KINASE". Page/Page column 34. . Retrieved 2008/06/13.