(3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine

Base Information

• Chemical Name: (3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine
• CAS No.: 101471-19-6
• Molecular Formula: C₁₁H₁₅F₂NO₂
• Molecular Weight: 231.242
• Mol file: 101471-19-6.mol

Synonyms:(3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine

Chemical Property of (3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine

There total 6 articles about (3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-difluorobromobenzene (461-96-1) → (3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine (101471-19-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating

2: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating

3: 0.33 h / Heating

4: sodium borohydride / ethanol / 24 h / Ambient temperature

With sodium tetrahydroborate; formic acid; nickel; In ethanol; N,N-dimethyl acetamide;

DOI:10.1021/jm00386a008

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → (3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine (101471-19-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 91 percent / Br₂ / acetic acid / 0.25 h / Ambient temperature

2: 1.) 12 N HCl, NaNO₂, 2.) 50 percent H₃PO₂ / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h

3: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating

4: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating

5: 0.33 h / Heating

6: sodium borohydride / ethanol / 24 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; formic acid; bromine; hypophosphorous acid; sodium nitrite; nickel; In ethanol; N,N-dimethyl acetamide; acetic acid;

DOI:10.1021/jm00386a008

Reference yield:

3,5-difluorobenzonitrile (64248-63-1) → (3,5-Difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine (101471-19-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating

2: 0.33 h / Heating

3: sodium borohydride / ethanol / 24 h / Ambient temperature

With sodium tetrahydroborate; formic acid; nickel; In ethanol;

DOI:10.1021/jm00386a008

upstream raw materials:

3,5-difluorobromobenzene

3,5-difluorobenzonitrile

3,5-difluorobenzaldehyde

2,4-difluorophenylamine

Downstream raw materials:

SKF 102698

Refernces

• 1、 Kruse, Lawrence I.,Kaiser, Carl,DeWolf, Walter E.,Frazee, James S.,Erickson, Robert W.,et al.. "Substituted 1-Benzylimidazole-2-thiols as Potent and Orally Active Inhibitors of Dopamine β-Hydroxylase". . p. 887 - 889. Retrieved 2007/10/02.