diethyl-(4-amino-phenethyl)-amine

Base Information

• Chemical Name: diethyl-(4-amino-phenethyl)-amine
• CAS No.: 1665-60-7
• Molecular Formula: C₁₂H₂₀N₂
• Molecular Weight: 192.304
• Mol file: 1665-60-7.mol

Synonyms:diethyl-(4-amino-phenethyl)-amine

Chemical Property of diethyl-(4-amino-phenethyl)-amine

Chemical Property:

Purity/Quality:

4-[2-(diethylamino)ethyl]aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl-(4-amino-phenethyl)-amine

There total 8 articles about diethyl-(4-amino-phenethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dibromo-1-(4-nitrophenyl)ethene (51738-10-4) → diethyl-(4-amino-phenethyl)-amine (1665-60-7)

Guidance literature:

Multi-step reaction with 3 steps

1: water / 20 °C

2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux

3: 10% palladium on activated charcoal; hydrogen / methanol

With sodium tetrahydroborate; 10% palladium on activated charcoal; boron trifluoride diethyl etherate; water; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2010.11.016

Reference yield:

diethyl-(4-nitro-phenethyl)-amine (5345-22-2) → diethyl-(4-amino-phenethyl)-amine (1665-60-7)

Guidance literature:

With 10% palladium on activated charcoal; hydrogen; In methanol;

DOI:10.1016/j.ejmech.2010.11.016

Reference yield:

Diethylamide of p-nitrophenylacetic acid (50507-86-3) → diethyl-(4-amino-phenethyl)-amine (1665-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux

2: 10% palladium on activated charcoal; hydrogen / methanol

With sodium tetrahydroborate; 10% palladium on activated charcoal; boron trifluoride diethyl etherate; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2010.11.016

upstream raw materials:

N,N-diethylphenethylamine

p-aminophenylacetonitrile

diethylamine

2-(4-nitrophenyl)ethyl chloride

Downstream raw materials:

benzothiazol-2-yl-[4-(2-diethylamino-ethyl)-phenyl]-amine

Refernces

• 1、 -. "BETA-KETOAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING SAID COMPOUNDS". Page/Page column 80. . Retrieved 2008/06/13.
• 2、 -. "2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES". Page 86. . Retrieved 2010/02/10.