3-Bromophenacyl bromide

Base Information

• Chemical Name: 3-Bromophenacyl bromide
• CAS No.: 18523-22-3
• Molecular Formula: C8H6Br2O
• Molecular Weight: 277.943
• Hs Code.: 29147000
• Mol file: 18523-22-3.mol

Synonyms:2-Bromo-1-(3-bromophenyl)ethanone;3'-Bromophenacyl Bromide;2,3'-Dibromoacetophenone;

Chemical Property of 3-Bromophenacyl bromide

Chemical Property:

• Appearance/Colour: light yellow crystalline powder
• Vapor Pressure: 0.0008mmHg at 25°C
• Melting Point: 47-52 °C
• Refractive Index: 1.603
• Boiling Point: 305.856 °C at 760 mmHg
• Flash Point: 111.496 °C
• PSA: 17.07000
• Density: 1.849 g/cm³
• LogP: 3.02670
• Storage Temp.: Keep Cold
• Sensitive.: Lachrymatory
• Solubility.: DMSO (Slightly)
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromophenacyl Bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: It is employed as an intermediate for pharmaceutical and organic synthesis. 3-Bromophenacyl bromide is a useful intermediate for pharmaceutical and organic synthesis.

Technology Process of 3-Bromophenacyl bromide

There total 9 articles about 3-Bromophenacyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2,3'-dibromoacetophenone (18523-22-3)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere;

In diethyl ether; dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

With hydrogen bromide; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield: 99.0%

1-(3-Bromophenyl)ethanone (2142-63-4) → 2,3'-dibromoacetophenone (18523-22-3)

Guidance literature:

With N-Bromosuccinimide; toluene-4-sulfonic acid; In dichloromethane; at 40 ℃; for 0.25h; Microwave irradiation; Green chemistry;

DOI:10.1002/jhet.3950

Reference yield: 93.0%

1-bromo-3-(bromoethynyl)benzene → 2,3'-dibromoacetophenone (18523-22-3)

Guidance literature:

With 2-(dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl Au bis(trifluoromethylsulfonyl)imide; water; In 1,2-dichloro-ethane; at 20 ℃; for 14h;

DOI:10.1021/jo401437w

upstream raw materials:

1-(3-Bromophenyl)ethanone

methyl carbamate

methanol

3-bromostyrene

Downstream raw materials:

methyl 4-[4-(3-bromophenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate

1,4-bis(3-bromophenyl)butane-1,4-dione

2-(3-Bromo-phenyl)-3-nitroso-imidazo[1,2-a]pyrimidine

4-[4-(3-bromophenyl)-1,3-dihydro-2(2H)-oxoimidazol-1-yl]-1-(1,1-dimethylethoxycarbonyl)-piperidine

Refernces

• 1、 Zhou, You,Lu, Xin,Du, Chenxi,Liu, Yijun,Wang, Yifan,Hong, Kwon Ho,Chen, Yao,Sun, Haopeng. "Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies". . . Retrieved 2021/01/07.
• 2、 Gaykar, Rahul N.,George, Malini,Guin, Avishek,Bhattacharjee, Subrata,Biju, Akkattu T.. "An umpolung oxa-[2,3] sigmatropic rearrangement employing arynes for the synthesis of functionalized enol ethers". supporting information. p. 3447 - 3452. Retrieved 2021/05/04.