Technology Process of axitinib
There total 4 articles about axitinib which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydrogencarbonate; tris-(dibenzylideneacetone)dipalladium(0) / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C / Inert atmosphere; Large scale
1.2: 3 h / 25 - 50 °C / Inert atmosphere; Large scale
2.1: iodine; potassium hydroxide / 1-methyl-pyrrolidin-2-one; water / 5.5 h / 25 °C / Inert atmosphere; Large scale
3.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1-methyl-pyrrolidin-2-one / 50 °C / Inert atmosphere; Large scale
With
tris-(dibenzylideneacetone)dipalladium(0); iodine; palladium diacetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide;
In
1-methyl-pyrrolidin-2-one; water;
1.1: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling) / 1.2: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);
DOI:10.1021/op400088k
- Guidance literature:
-
With
palladium diacetate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1-methyl-pyrrolidin-2-one;
at 50 ℃;
Inert atmosphere;
Large scale;
DOI:10.1021/op400088k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydrogencarbonate; tris-(dibenzylideneacetone)dipalladium(0) / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C / Inert atmosphere; Large scale
1.2: 3 h / 25 - 50 °C / Inert atmosphere; Large scale
2.1: iodine; potassium hydroxide / 1-methyl-pyrrolidin-2-one; water / 5.5 h / 25 °C / Inert atmosphere; Large scale
3.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1-methyl-pyrrolidin-2-one / 50 °C / Inert atmosphere; Large scale
With
tris-(dibenzylideneacetone)dipalladium(0); iodine; palladium diacetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide;
In
1-methyl-pyrrolidin-2-one; water;
1.1: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling) / 1.2: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);
DOI:10.1021/op400088k
