Technology Process of 3-fluoro-N-((2,5,5-trimethylcyclopent-1-enyl)methyl)aniline hydrochloride
There total 7 articles about 3-fluoro-N-((2,5,5-trimethylcyclopent-1-enyl)methyl)aniline hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether;
at 20 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogenchloride / methanol; water / 1 h / pH 1 / Reflux
2: zinc(II) iodide / dichloromethane / 4 h / 20 °C
3: hydrogenchloride / tetrahydrofuran; water / 4 h / 45 °C
4: thionyl chloride / 84 °C / Sealed tube
5: diisobutylaluminium hydride / hexane / 2 h / -78 °C / Inert atmosphere
6: acetic acid; sodium cyanoborohydride / methanol / 20 °C
7: hydrogenchloride / diethyl ether / 0.25 h / 20 °C
With
hydrogenchloride; thionyl chloride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; zinc(II) iodide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: zinc(II) iodide / dichloromethane / 4 h / 20 °C
2: hydrogenchloride / tetrahydrofuran; water / 4 h / 45 °C
3: thionyl chloride / 84 °C / Sealed tube
4: diisobutylaluminium hydride / hexane / 2 h / -78 °C / Inert atmosphere
5: acetic acid; sodium cyanoborohydride / methanol / 20 °C
6: hydrogenchloride / diethyl ether / 0.25 h / 20 °C
With
hydrogenchloride; thionyl chloride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; zinc(II) iodide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
