1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde

Base Information

• Chemical Name: 1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde
• CAS No.: 74567-31-0
• Molecular Formula: C₁₆H₂₀O₄
• Molecular Weight: 276.332
• Mol file: 74567-31-0.mol

Synonyms:1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde

Chemical Property of 1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde

There total 3 articles about 1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohexylidenemethyl-[1-phenyl-meth-(E)-ylidene]-amine (64244-35-5) → 1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde (74567-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1) THF, hexane, -78 deg C, 1 h; 2) 30 min, THF

2: tetrahydrofuran / 1) -78 deg C, 1 h; 2) -78 deg C --> room temperature, 2 - 3 h

With n-butyllithium; In tetrahydrofuran;

DOI:10.1021/ja00538a027

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde (74567-31-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-butyllithium / 1) THF, -78 deg C, 1 h; 2) THF, reflux, 2 h

2: 1.) n-butyllithium / 1) THF, hexane, -78 deg C, 1 h; 2) 30 min, THF

3: tetrahydrofuran / 1) -78 deg C, 1 h; 2) -78 deg C --> room temperature, 2 - 3 h

With n-butyllithium; In tetrahydrofuran;

DOI:10.1021/ja00538a027

Reference yield:

1-(hydroxy(phenyl)methyl)cyclohexane-1-carbaldehyde (208348-82-7) + methyl chloroformate (79-22-1) → 1-(1'-methoxycarbonyloxybenzyl)cyclohexanecarboxaldehyde (74567-31-0)

Guidance literature:

In tetrahydrofuran; Yield given; 1) -78 deg C, 1 h; 2) -78 deg C --> room temperature, 2 - 3 h;

DOI:10.1021/ja00538a027

upstream raw materials:

1-(hydroxy(phenyl)methyl)cyclohexane-1-carbaldehyde

methyl chloroformate

Cyclohexylidenemethyl-[1-phenyl-meth-(E)-ylidene]-amine

cyclohexanone

Refernces