C₁₅H₂₃NOSi

Base Information

• Chemical Name: C₁₅H₂₃NOSi
• CAS No.: 1314664-72-6
• Molecular Formula: C₁₅H₂₃NOSi
• Molecular Weight: 261.439
• Mol file: 1314664-72-6.mol

Synonyms:C₁₅H₂₃NOSi

Chemical Property of C₁₅H₂₃NOSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₃NOSi

There total 2 articles about C₁₅H₂₃NOSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-dimethylamino-o-tolualdehyde (1199-59-3) + trimethylsilylacetylene (1066-54-2) → C15H23NOSi (1314664-72-6)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

4-dimethylamino-o-tolualdehyde; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

DOI:10.1002/chem.201100729

Reference yield:

4-fluoro-2-methylbenzaldehyde (63082-45-1) → C15H23NOSi (1314664-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / water / 24 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; water;

DOI:10.1002/chem.201100729

Reference yield:

Octanal (124-13-0) + C15H23NOSi (1314664-72-6) → C23H37NOSi + C23H37NOSi

Guidance literature:

With (2S)-2-benzyl-4-methyl-1,4-diaza-spiro[4.4]nonan-3-one; indium(lll) trifluoromethanesulfonate; In water; acetonitrile; at 0 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201100729

upstream raw materials:

4-fluoro-2-methylbenzaldehyde

4-dimethylamino-o-tolualdehyde

trimethylsilylacetylene

Refernces