Technology Process of 3-((1S,2S)-2-hydroxycyclohexyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzo[h]quinazolin-4(3H)-one
There total 12 articles about 3-((1S,2S)-2-hydroxycyclohexyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzo[h]quinazolin-4(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate;
In
1,4-dioxane;
at 90 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00095
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 15 h / 20 °C / Inert atmosphere
2: 2 h / 80 °C / Inert atmosphere
3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine;
In
1,4-dioxane;
DOI:10.1021/acsmedchemlett.8b00095
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide / 24 h / 125 - 135 °C
2.1: potassium carbonate; potassium permanganate / tetrahydrofuran; water / 2 h / 0 - 20 °C
3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 10 h / 20 °C / 2052.96 Torr
4.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran; water / 1 h / 0 - 15 °C
5.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 2-methyltetrahydrofuran / 2 h / 20 °C
5.2: 2 h / 20 °C
6.1: N,N-dimethyl-formamide / 2 h / 70 - 80 °C
7.1: potassium acetate; chloro[(tricyclohexylphosphine)-2-(2'-aminobiphenyl)]palladium(II) second generation / tetrahydrofuran / 23 h / 67 °C
With
potassium permanganate; N-Bromosuccinimide; palladium 10% on activated carbon; chloro[(tricyclohexylphosphine)-2-(2'-aminobiphenyl)]palladium(II) second generation; hydrogen; potassium acetate; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine;
In
tetrahydrofuran; 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide;