O-dibenzyl phosphoric acid ester of (R)-bicalutamide

Base Information

• Chemical Name: O-dibenzyl phosphoric acid ester of (R)-bicalutamide
• CAS No.: 1259485-93-2
• Molecular Formula: C₃₂H₂₇F₄N₂O₇PS
• Molecular Weight: 690.609
• Mol file: 1259485-93-2.mol

Synonyms:O-dibenzyl phosphoric acid ester of (R)-bicalutamide

Chemical Property of O-dibenzyl phosphoric acid ester of (R)-bicalutamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-dibenzyl phosphoric acid ester of (R)-bicalutamide

There total 1 articles about O-dibenzyl phosphoric acid ester of (R)-bicalutamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) + (R)-bicalutamide (90357-06-5,113299-38-0,151262-58-7,113299-40-4) → O-dibenzyl phosphoric acid ester of (R)-bicalutamide (1259485-93-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 3h;

Reference yield: 85.0%

O-dibenzyl phosphoric acid ester of (R)-bicalutamide (1259485-93-2) → phosphoric acid ester of (R)-bicalutamide (1226897-60-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

O-dibenzyl phosphoric acid ester of (R)-bicalutamide (1259485-93-2) → phosphoric acid ester dicalcium salt of (R)-bicalutamide

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2: sodium hydroxide / di-isopropyl ether; methanol / 3.5 h / 0 - 20 °C

With hydrogen; sodium hydroxide; palladium 10% on activated carbon; In methanol; di-isopropyl ether;

upstream raw materials:

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

(R)-bicalutamide

Downstream raw materials:

phosphoric acid ester of (R)-bicalutamide

Refernces