6-Methylprogesteron-17-pivalate

Base Information

• Chemical Name: 6-Methylprogesteron-17-pivalate
• CAS No.: 86098-91-1
• Molecular Formula: C₂₇H₄₀O₄
• Molecular Weight: 428.612
• Mol file: 86098-91-1.mol

Synonyms:2,2-Dimethyl-propionic acid (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester;

Chemical Property of 6-Methylprogesteron-17-pivalate

Chemical Property:

• PSA: 60.44000
• LogP: 5.68140

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methylprogesteron-17-pivalate

There total 5 articles about 6-Methylprogesteron-17-pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6-Methylen-17-trimethylacetoxy-4-pregnen-3,20-dion (86098-90-0) → 6α-Methyl-17-trimethylacetoxy-4-pregnen-3,20-dion (86098-91-1)

Guidance literature:

With isopropyl alcohol; palladium on activated charcoal; In cyclohexene; for 1h; Heating;

DOI:10.1002/jlac.198319830420

Reference yield:

17-Trimethylacetoxy-4-pregnen-3,20-dion (86098-87-5) → 6α-Methyl-17-trimethylacetoxy-4-pregnen-3,20-dion (86098-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / NaOAc, POCl₃ / CHCl₃ / 6 h / 70 °C

2: 81 percent / propan-2-ol / Pd/C (9.64 percent) / cyclohexene / 1 h / Heating

With sodium acetate; isopropyl alcohol; trichlorophosphate; palladium on activated charcoal; In chloroform; cyclohexene;

DOI:10.1002/jlac.198319830420

Reference yield:

21-Brom-17-trimethylacetoxy-4-pregnen-3,20-dion (86098-86-4) → 6α-Methyl-17-trimethylacetoxy-4-pregnen-3,20-dion (86098-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / (Bu)3SnH, AIBN / tetrahydrofuran / 8 h / 50 °C

2: 54 percent / NaOAc, POCl₃ / CHCl₃ / 6 h / 70 °C

3: 81 percent / propan-2-ol / Pd/C (9.64 percent) / cyclohexene / 1 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium acetate; isopropyl alcohol; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; chloroform; cyclohexene;

DOI:10.1002/jlac.198319830420

upstream raw materials:

6-Methylen-17-trimethylacetoxy-4-pregnen-3,20-dion

17-Trimethylacetoxy-4-pregnen-3,20-dion

21-Brom-17-trimethylacetoxy-4-pregnen-3,20-dion

2,2-Dimethyl-propionic acid (8R,9S,10R,13S,14S,17R)-17-(2-hydroxy-acetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Refernces