2-Furamide

Base Information

• Chemical Name: 2-Furamide
• CAS No.: 609-38-1
• Molecular Formula: C5H5NO2
• Molecular Weight: 111.1
• Hs Code.: 2932190090
• NSC Number: 9351
• UNII: 8IG4632C1Y
• DSSTox Substance ID: DTXSID0060569
• Nikkaji Number: J95.456J
• Wikidata: Q9264702
• Mol file: 609-38-1.mol

Synonyms:2,2-dichloro-4'-hydroxy-N-methylacetanilide 2-furoate;2-furamide;diloxanide;diloxanide furoate;entamide furoate;Furamide

Chemical Property of 2-Furamide

Chemical Property:

• Appearance/Colour: light yellow scales crystalline
• Vapor Pressure: 0.00536mmHg at 25°C
• Melting Point: 138-140°C
• Refractive Index: 1.516
• Boiling Point: 275℃
• PKA: 15.66±0.50(Predicted)
• Flash Point: 120℃
• PSA: 56.23000
• Density: 1.221 g/cm³
• LogP: 1.07880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 111.032028402
• Heavy Atom Count: 8
• Complexity: 103

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Furamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)C(=O)N

Technology Process of 2-Furamide

There total 15 articles about 2-Furamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) → 2-furancarbonitrile (617-90-3) + furan-2-carboxylic acid amide (609-38-1)

Guidance literature:

With ammonia; oxygen; In tert-Amyl alcohol; water; at 100 ℃; for 14h; under 3750.38 Torr; Overall yield = > 99 percent; Autoclave; High pressure;

DOI:10.1021/acscatal.0c00485

Reference yield: 85.0%

2-furaldehyde oxime (1121-47-7) → furfural (98-01-1) + furan-2-carboxylic acid amide (609-38-1)

Guidance literature:

With tin(II) chloride dihdyrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 10h; Reflux;

Reference yield: 81.0%

N′-hydroxyfuran-2-carboximidamide (50892-99-4,261734-99-0) → 2-furancarbonitrile (617-90-3) + furan-2-carboxylic acid amide (609-38-1)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; acetonitrile; at 20 ℃; for 0.833333h;

DOI:10.3998/ark.5550190.0011.209

upstream raw materials:

2-ethanol

2-furancarbonitrile

furfural

N′-hydroxyfuran-2-carboximidamide

Downstream raw materials:

furan-2-carboxylic acid phenylamide

propyl furan-2-carboxylate

N-benzoylfuran-2-carboxamide

N-(4-chlorophenyl)furan-2-carboxamide

Refernces

• 1、 Ren, Yun-Lai,Shen, Zhenpeng,Tian, Xinzhe,Xing, Ai-Ping,Zhao, Zhe. "CuO-catalyzed conversion of arylacetic acids into aromatic nitriles with K4Fe(CN)6 as the nitrogen source". . . Retrieved 2020/10/26.
• 2、 Ma, Xiaoyun,Ao, Jun,Chen, Zhengjian,Liu, Yi. "Copper (II)-catalysed direct conversion of aldehydes into nitriles in acetonitrile". . p. 465 - 468. Retrieved 2017/08/18.