2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol

Base Information

• Chemical Name: 2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol
• CAS No.: 85958-24-3
• Molecular Formula: C₄H₁₁NO₃*C₁₇H₁₆N₂O₇S₂
• Molecular Weight: 545.591
• Mol file: 85958-24-3.mol

Synonyms:2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol

Chemical Property of 2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol

There total 6 articles about 2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Protonated tris(hydroxymethyl)aminoamethane (19320-52-6) + phenyl N-furfuryl-4-phenoxy-5-sulfamoylothanilate (82749-80-2) → 2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol (85958-24-3)

Guidance literature:

With hydrogen; 2-amino-2-hydroxymethyl-1,3-propanediol; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; under 75.006 Torr;

DOI:10.1021/jm00362a017

Reference yield:

furan-2-ylmethanamine (617-89-0) → 2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol (85958-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / propan-2-ol / 10 h / Heating

2: H₂, H₃NC(CH₂OH)3 / 10percent Pd/C / tetrahydrofuran / 20 °C / 75.01 Torr

With hydrogen; 2-amino-2-hydroxymethyl-1,3-propanediol; palladium on activated charcoal; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1021/jm00362a017

Reference yield:

4,6-dichlorobenzene-1,3-disulfonyl chloride (61791-73-9) → 2-[(Furan-2-ylmethyl)-amino]-4-phenoxy-5-sulfamoyl-benzenesulfonic acid; compound with 2-amino-2-hydroxymethyl-propane-1,3-diol (85958-24-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NH₃ / 1.) THF, 5-10 deg C, 2 h, 2.) MeOH, a) reflux, 10 min, b) RT, overnight

2: 50 percent / butan-2-one / 6 h / Heating

3: 52 percent / propan-2-ol / 10 h / Heating

4: H₂, H₃NC(CH₂OH)3 / 10percent Pd/C / tetrahydrofuran / 20 °C / 75.01 Torr

With ammonia; hydrogen; 2-amino-2-hydroxymethyl-1,3-propanediol; palladium on activated charcoal; In tetrahydrofuran; isopropyl alcohol; butanone;

DOI:10.1021/jm00362a017

upstream raw materials:

Protonated tris(hydroxymethyl)aminoamethane

phenyl N-furfuryl-4-phenoxy-5-sulfamoylothanilate

furan-2-ylmethanamine

4,6-dichlorobenzene-1,3-disulfonyl chloride

Refernces