methyl 4-acryloyl-benzoate

Base Information

• Chemical Name: methyl 4-acryloyl-benzoate
• CAS No.: 187401-48-5
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.199
• Mol file: 187401-48-5.mol

Synonyms:methyl 4-acryloyl-benzoate

Chemical Property of methyl 4-acryloyl-benzoate

Chemical Property:

Purity/Quality:

4-Acryloylbenzoic acid methyl ester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-acryloyl-benzoate

There total 9 articles about methyl 4-acryloyl-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + methyl 4-acetylbenzoate (3609-53-8) → methyl 4-acryloyl-benzoate (187401-48-5)

Guidance literature:

With potassium carbonate; triphenylphosphine; at 20 ℃; for 6h; Irradiation; Green chemistry;

DOI:10.1002/adsc.201801431

Reference yield: 74.0%

1-(4'-(methoxycarbonyl)phenyl)-allylalcohol (196519-53-6) → methyl 4-acryloyl-benzoate (187401-48-5)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/chem.201903590

Reference yield: 67.0%

methyl 4-acetylbenzoate (3609-53-8) + dimethyl sulfoxide (67-68-5,8070-53-9) → methyl 4-acryloyl-benzoate (187401-48-5)

Guidance literature:

With dipotassium peroxodisulfate; sodium acetate; at 120 ℃; for 9h; Schlenk technique;

DOI:10.1021/acs.joc.7b00619

upstream raw materials:

1-(4'-(methoxycarbonyl)phenyl)-allylalcohol

methyl 4-formylbenzoate

dipyridinium dichromate

vinyl magnesium bromide

Downstream raw materials:

methyl 4-[4-oxo-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)butanoyl]benzoate

4-[4-(8-isopropyl-4-phenyl-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester

4-[4-(4-ethyl-8-isopropyl-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester

4-[4-(8-isopropyl-4-methoxy-quinolin-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester

Refernces

• 1、 Zeng, Weijun,Tan, Xuefeng,Yu, Yang,Chen, Gen-Qiang,Zhang, Xumu. "Copper-Catalyzed Asymmetric Hydrosilylation of β-Nitroethyl Aryl Ketones". supporting information. p. 858 - 862. Retrieved 2020/01/31.
• 2、 Zhang, Yong-Hui,Zhang, Wen-Wei,Zhang, Ze-Yu,Zhao, Kai,Loh, Teck-Peng. "Manganese-Catalyzed Ring-Opening Coupling Reactions of Cyclopropanols with Enones". supporting information. p. 5101 - 5105. Retrieved 2019/07/03.