5-Hydroxy-6-methyl-2-pyridineoctanoic acid

Base Information

• Chemical Name: 5-Hydroxy-6-methyl-2-pyridineoctanoic acid
• CAS No.: 501-18-8
• Molecular Formula: C14H21NO3
• Molecular Weight: 251.326
• DSSTox Substance ID: DTXSID101264870
• Mol file: 501-18-8.mol

Synonyms:DTXSID101264870;5-Hydroxy-6-methyl-2-pyridineoctanoic acid;501-18-8

Chemical Property of 5-Hydroxy-6-methyl-2-pyridineoctanoic acid

Chemical Property:

• Boiling Point: 489.5±45.0 °C(Predicted)
• PSA: 70.42000
• Density: 1.122±0.06 g/cm3(Predicted)
• LogP: 3.06330
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 251.15214353
• Heavy Atom Count: 18
• Complexity: 245

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)CCCCCCCC(=O)O)O

Technology Process of 5-Hydroxy-6-methyl-2-pyridineoctanoic acid

There total 1 articles about 5-Hydroxy-6-methyl-2-pyridineoctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(2-furyl)-3-oxopropanoate (615-09-8) → 8-(5-Hydroxy-6-methyl-2-pyridinyl)octansaeure (501-18-8)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium ethylate; ethanol / anschliessendes Erwaermen mit 6-Brom-hexansaeure-aethylester in Benzol

2: aqueous KOH-solution / Erhitzen des Reaktionsprodukts mit wss. Schwefelsaeure

3: hydrazine hydrate; sodium hydroxide; ethylene glycol / 150 °C / Entfernen des entstehenden Wassers und Erhitzen des Reaktionsprodukts mit Toluol und wss.-aethanol. Natronlauge

4: benzene; sulfuric acid

5: boron fluoride ether adduct

6: Hydrolysis_.Erhitzen des Reaktionsprodukts mit wss. NH₃ und wenig NH₄Cl auf 165grad, Behandeln mit wss. NaOH und Behandeln der erhaltenen Saeure mit Aethanol und HCl

7: methanol. KOH

With potassium hydroxide; sodium hydroxide; ethanol; boron fluoride ether; sulfuric acid; sodium ethanolate; hydrazine hydrate; ethylene glycol; benzene;

upstream raw materials:

ethyl 3-(2-furyl)-3-oxopropanoate