Multi-step reaction with 4 steps
1: 34 percent / 1.) 1 N, NaOH, sodium nitrite, 2.) aq. HCl, LiCl / 1.) 55 deg C, 2.) 45 deg C, 15 min
2: 88 percent / NaSH*xH2O / dimethylformamide / 1.) 0 deg C, overnight, 2.) RT, 2 h
3: 74 percent / 1 N NaOH, 30percent H2O2 / H2O / 1.) RT, 1 h, 2.) 70 deg C, 1 h
4: 1.) HMDS, (NH4)2SO4, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) pyridine, reflux, 4 h, 2.) acetonitrile, RT, overnight
With
hydrogenchloride; ammonium sulfate; sodium hydroxide; sodium hydrogensulfide; trimethylsilyl trifluoromethanesulfonate; dihydrogen peroxide; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; sodium nitrite;
In
water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a064