α,α'-[(1,2,5-Oxadiazole 5-oxide)-3,4-diyl]bisbenzaldehyde

Base Information

• Chemical Name: α,α'-[(1,2,5-Oxadiazole 5-oxide)-3,4-diyl]bisbenzaldehyde
• CAS No.: 6635-54-7
• Molecular Formula: C16H10N2O4
• Molecular Weight: 294.266
• Mol file: 6635-54-7.mol

Synonyms:3,4-dibenzoyl-1,2,5-oxadiazole-N-oxide;C,C'-diphenyl-C,C'-(2-oxy-furazan-3,4-diyl)-bis-methanone;3,4-Dibenzoylfuroxan;dibenzoylfurazan 2-oxide;3,4-dibenzoyl-furazan 2-oxide;Furazan (8CI),2-oxide;Furazan (9CI),methanone deriv.;Dibenzoylfuroxane;Dibenzoylfuroxan;

Chemical Property of α,α'-[(1,2,5-Oxadiazole 5-oxide)-3,4-diyl]bisbenzaldehyde

Chemical Property:

• Vapor Pressure: 2.2E-11mmHg at 25°C
• Boiling Point: 531.7°C at 760 mmHg
• Flash Point: 275.3°C
• PSA: 85.63000
• Density: 1.34g/cm³
• LogP: 2.56510

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dibenzoylforoxan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α'-[(1,2,5-Oxadiazole 5-oxide)-3,4-diyl]bisbenzaldehyde

There total 39 articles about α,α'-[(1,2,5-Oxadiazole 5-oxide)-3,4-diyl]bisbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-diazo-acetophenone (3282-32-4) → 3,4-dibenzoyl-1,2,5-oxadiazole-N-oxide (6635-54-7)

Guidance literature:

With tert.-butylnitrite; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/acs.orglett.0c04130

Reference yield: 95.0%

tert.-butylnitrite (540-80-7) + acetophenone (98-86-2) → 3,4-dibenzoyl-1,2,5-oxadiazole-N-oxide (6635-54-7)

Guidance literature:

With air; In 1,4-dioxane; at 20 - 60 ℃; for 24h;

Reference yield: 92.0%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one (20718-17-6) → 3,4-dibenzoyl-1,2,5-oxadiazole-N-oxide (6635-54-7)

Guidance literature:

With tert.-butylnitrite; sodium acetate; In 1,4-dioxane; at 40 ℃; for 2h; Solvent; Temperature; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01876

upstream raw materials:

N-hydroxy-2-oxo-2-phenylethanimidoyl chloride

diethyl ether

silver(I) acetate

silver benzoate

Downstream raw materials:

(4-nitroso-5-phenyl-isoxazol-3-yl)-phenyl-amine

4-nitroso-5-phenyl-3-(N'-phenyl-hydrazino)-isoxazole

isoxazol-3-yl(phenyl)methanone

(4-amino-1,2,5-oxadiazol-3-yl)(phenyl)methanone

Refernces

• 1、 de Angelis, Luca,Crawford, Alexandra M.,Su, Yong-Liang,Wherritt, Daniel,Arman, Hadi,Doyle, Michael P.. "Catalyst-free formation of nitrile oxides and their further transformations to diverse heterocycles". supporting information. p. 925 - 929. Retrieved 2021/01/26.
• 2、 Gu, Zhen-Zhen,Guo, Feng-Chao,Zhang, Pu,Qin, Yu-Jun,Guo, Zhi-Xin. "Solvent-free mechanochemical synthesis of diacylfuroxans". supporting information. p. 1687 - 1690. Retrieved 2019/06/05.