(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Base Information

• Chemical Name: (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate
• CAS No.: 1175536-51-2
• Molecular Formula: C₁₃H₁₄F₂N₄OS*H₂O₄S
• Molecular Weight: 410.423
• Mol file: 1175536-51-2.mol

Synonyms:(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Chemical Property of (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

There total 1 articles about (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile (170862-36-9) → (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate (1175536-51-2)

Guidance literature:

(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile; With O,O-Diethyl hydrogen phosphorodithioate; In water; isopropyl alcohol; at 75 - 80 ℃; for 9h; Large scale reaction;

With sodium hydroxide; In water; ethyl acetate; isopropyl alcohol; at 10 - 20 ℃; pH=8.1; Large scale reaction;

With sulfuric acid; In ethyl acetate; isopropyl alcohol; at 23 - 40 ℃; Large scale reaction;

DOI:10.1021/op900065c

Reference yield: 85.8%

(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate (1175536-51-2) + 4-Cyanophenacyl bromide (20099-89-2) → ravuconazole (182760-06-1)

Guidance literature:

(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate; 4-Cyanophenacyl bromide; In ethanol; water; at 60 - 70 ℃; for 2h; Large scale reaction;

With triethylamine; In ethanol; water; at 55 - 70 ℃; pH=3.5 - 4; Large scale reaction;

DOI:10.1021/op900065c

upstream raw materials:

(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile

Downstream raw materials:

ravuconazole

Refernces