Formic Acid

Base Information

• Chemical Name: Formic Acid
• CAS No.: 64-18-6
• Deprecated CAS: 8006-93-7,82069-14-5,1016316-60-1,67382-92-7,1016316-60-1,67382-92-7,82069-14-5
• Molecular Formula: CH2O2
• Molecular Weight: 46.0257
• Hs Code.: 2915.11
• European Community (EC) Number: 200-579-1,213-599-0
• ICSC Number: 0485
• UN Number: 1779
• UNII: 0YIW783RG1
• DSSTox Substance ID: DTXSID2024115
• Nikkaji Number: J1.402H
• Wikipedia: Formic acid
• Wikidata: Q161233,Q27110013
• NCI Thesaurus Code: C83719
• RXCUI: 4537
• Metabolomics Workbench ID: 37099
• ChEMBL ID: CHEMBL116736
• Mol file: 64-18-6.mol

Synonyms:aluminum formate;ammonium formate;ammonium tetraformate;calcium formate;chromic formate;cobalt(II) formate dihydrate;cobaltous formate;cupric formate;formate;formic acid;formic acid, 14C-labeled;formic acid, aluminum salt;formic acid, ammonium (2:1) salt;formic acid, ammonium (4:1) salt;formic acid, ammonium salt;formic acid, cadmium salt;formic acid, calcium salt;formic acid, cesium salt;formic acid, cobalt (+2) salt;formic acid, copper (+2) salt;formic acid, copper salt;formic acid, copper, ammonium salt;formic acid, copper, nickel salt;formic acid, cromium (+3) salt;formic acid, cromium (+3), sodium (4:1:1) salt;formic acid, lead (+2) salt;formic acid, lead salt;formic acid, lithium salt;formic acid, magnesium salt;formic acid, nickel (+2) salt;formic acid, nickel salt;formic acid, potassium salt;formic acid, rubidium salt;formic acid, sodium salt;formic acid, sodium salt, 13C-labeled;formic acid, sodium salt, 14C-labeled;formic acid, strontium salt;formic acid, thallium (+1) salt;formic acid, zinc salt;lead formate;lithium formate;magnesium formate;methanoic acid;nickel formate;nickel formate dihydrate;potassium formate;sodium formate;strontium formate;zinc formate

Chemical Property of Formic Acid

Chemical Property:

• Appearance/Colour: colorless liquid with a pungent odor
• Melting Point: 8 °C
• Refractive Index: n20/D 1.377
• Boiling Point: 100.56 °C at 760 mmHg
• Flash Point: 29.888 °C
• PSA: 37.30000
• Density: 1.155 g/cm³
• LogP: 0.33670
• Water Solubility.: MISCIBLE
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 46.005479302
• Heavy Atom Count: 3
• Complexity: 10.3
• Transport DOT Label: Corrosive Flammable Liquid

Purity/Quality:

85%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): T, C, Xi
• Hazard Codes: C:Corrosive
• Statements: R35:
• Safety Statements: S23:; S26:; S45:

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: C(=O)O
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is very corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The substance may cause effects on the energy metabolism. This may result in acidosis.

Technology Process of Formic Acid

There total 3339 articles about Formic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-nitrophenyl) formate (1865-01-6) → formic acid (64-18-6) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0)

Guidance literature:

With acetate buffer; potassium chloride; water; at 25 ℃; Rate constant; var. anions as catalysts;

DOI:10.1021/ja00067a020

Reference yield:

1-Neopentylamino-3-(4-nitrophenylimino)-1,2-diphenyl-1-propen (78956-24-8) → phenyl benzyl ketone (451-40-1) + formic acid (64-18-6) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; Heating; acid hydrolysis; other reagent: conc. H₂SO₄/glacial acetic acid, multistep reaction;

Reference yield:

1-Benzylamino-3-(4-nitrophenylimino)-1,2-diphenyl-1-propen (78956-27-1) → phenyl benzyl ketone (451-40-1) + formic acid (64-18-6) + 4-nitro-aniline (100-01-6,104810-17-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; Heating; acid hydrolysis; other reagent: conc. H₂SO₄/glacial acetic acid, multistep reaction;

upstream raw materials:

nitrobenzene

1,4-dioxane

1-methyl-4-nitrosobenzene

AnCoA₄

Downstream raw materials:

ethylene glycol monoformate

ethylene glycol diformate

1-pyrrolidinecarboxaldehyde

N-Benzylpiperidine

Refernces

• 1、 Hofmann. "-". . . Retrieved 1863.
• 2、 Kiani?ka, Jana,?ík, Gabriel,?er?eň, Franti?ek,?pánik, Ivan,Sokolík, Robert,Filo, Juraj. "Photo-reduction of CO2 by vis light on polythiophene-ZSM-5 zeolite hybrid photo-catalyst". . . Retrieved 2019.
• 3、 Perlin. "-". . p. 396,397. Retrieved 1955.
• 4、 Noszticzius, Zoltan,McCormick, William D.,Swinney, Harry L.. "Use of Bifurcation Diagrams as Fingerprints of Chemical Mechanisms". . p. 2796 - 2800. Retrieved 1989.
• 5、 Loring et al.. "". . p. 3724,3727. Retrieved 1956.
• 6、 Shavi, Raghavendra,Hiremath, Vishwanath,Seo, Jeong Gil. "Radical-initiated oxidative conversion of methane to methanol over metallic iron and copper catalysts". . p. 232 - 239. Retrieved 2018.
• 7、 Xie, Ruigang,Chen, Muzi,Wang, Jiaqing,Mei, Sujuan,Pan, Yue,Gu, Hongwei. "Facile synthesis of Au-Pt bimetallic nanocomplexes for direct oxidation of methanol and formic acid". . p. 650 - 653. Retrieved 2015.
• 8、 Gao, Shutao,Feng, Tao,Wu, Qiuhua,Feng, Cheng,Shang, Ningzhao,Wang, Chun. "Immobilizing AgPd alloy on Vulcan XC-72 carbon: a novel catalyst for highly efficient hydrogen generation from formaldehyde aqueous solution". . p. 105638 - 105643. Retrieved 2016.
• 9、 Slebocka-Tilk,Neverov, Alexei A.,Brown. "Proton inventory study of the base-catalyzed hydrolysis of formamide. Consideration of the nucleophilic and general base mechanisms". . p. 1851 - 1858. Retrieved 2003.
• 10、 Dong, Guang-Xing,Zhang, Wen,Mu, Yan-Fei,Su, Ke,Zhang, Min,Lu, Tong-Bu. "A halide perovskite as a catalyst to simultaneously achieve efficient photocatalytic CO2 reduction and methanol oxidation". . p. 4664 - 4667. Retrieved 2020.