Technology Process of methyl 5-[(2-{[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]carbonyl}hydrazino)carbonyl]nicotinate
There total 6 articles about methyl 5-[(2-{[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]carbonyl}hydrazino)carbonyl]nicotinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 10.25 h / 0 - 60 °C
1.2: 0 °C
2.1: tert.-butylnitrite; copper dichloride / acetonitrile / 1.58 h / 20 °C
3.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C
4.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 12 h / 60 °C
5.1: hydrazine / methanol / 3 h / 70 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
With
lithium aluminium tetrahydride; tert.-butylnitrite; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; copper dichloride; hydrazine;
copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tert.-butylnitrite; copper dichloride / acetonitrile / 1.58 h / 20 °C
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C
3: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 12 h / 60 °C
4: hydrazine / methanol / 3 h / 70 °C
5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
With
tert.-butylnitrite; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; copper dichloride; hydrazine;
copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
