Phenylalanylglycine

Base Information

• Chemical Name: Phenylalanylglycine
• CAS No.: 4294-26-2
• Molecular Formula: C11H14N2O3
• Molecular Weight: 222.244
• Hs Code.: 2924299090
• NSC Number: 126855,89183,163390,118489,89182
• Mol file: 4294-26-2.mol

Synonyms:L-phenylalanylglycine;Phe-GLy;phenylalanylglycine

Chemical Property of Phenylalanylglycine

Chemical Property:

• Melting Point: >229° (dec.)
• PKA: pK1:3.10(+1);pK2:7.71(0) (25°C,μ=0.01)
• PSA: 92.42000
• LogP: 0.84840
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Sparingly, Sonicated)
• XLogP3: -2.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 222.10044231
• Heavy Atom Count: 16
• Complexity: 250

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C(=O)NCC(=O)O)N
• Uses: Phenylalanylglycine can be used to mask unpleasant taste impressions.

Technology Process of Phenylalanylglycine

There total 15 articles about Phenylalanylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(S)-2-(2-{(S)-2-[2-((S)-2-Amino-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoylamino}-acetylamino)-3-methyl-butyrylamino]-acetic acid (85864-65-9) → Glycine anhydride (106-57-0) + N-DL-valyl-glycine (14297-28-0,6491-60-7) + DL-Leucyl-glycin (615-82-7) + phenylalanylglycine (4294-26-2) + 3-isopropyl-piperazine-2,5-dione (16944-60-8) + 3-benzyl-piperazine-2,5-dione (10125-07-2)

Guidance literature:

In water; at 100 ℃; Product distribution; Mechanism; pH_7.26;

DOI:10.1021/jo00161a036

Reference yield:

2-(2-(tert-butoxycarbonylamino)-3-phenylpropanamido)acetic acid (4530-39-6) → phenylalanylglycine (4294-26-2)

Guidance literature:

With nitromethane; hydrogen bromide;

DOI:10.1021/ja01574a029

Reference yield:

N-(2-benzyloxyimino-3-phenyl-propionyl)-glycine → phenylalanylglycine (4294-26-2)

Guidance literature:

With ammonium hydroxide; Hydrogenation;

upstream raw materials:

glycine

4-benzyl-oxazolidine-2,5-dione

2-(2-(tert-butoxycarbonylamino)-3-phenylpropanamido)acetic acid

N-(N,N-phthaloyl-DL-phenylalanyl)-glycine

Downstream raw materials:

glycyl=>DL-phenylalanyl=>glycine

[(S)-2-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]acetic acid ethyl ester

4-benzyl-2-thioxo-thiazolidin-5-one

(S)-PheGly

Refernces