3,3'-difluorobenzidine

Base Information

• Chemical Name: 3,3'-difluorobenzidine
• CAS No.: 448-97-5
• Molecular Formula: C12H10 F2 N2
• Molecular Weight: 220.222
• Hs Code.: 2921590090
• Mol file: 448-97-5.mol

Synonyms:Benzidine,3,3'-difluoro- (6CI,8CI)

Chemical Property of 3,3'-difluorobenzidine

Chemical Property:

• Boiling Point: 335.8°Cat760mmHg
• Flash Point: 152.2°C
• PSA: 52.04000
• Density: 1.313g/cm³
• LogP: 3.95860
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4,4''-Diamino-3,3''-difluorobiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,4''-Diamino-3,3''-difluorobiphenyl

Technology Process of 3,3'-difluorobenzidine

There total 5 articles about 3,3'-difluorobenzidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

4-bromo-2-fluoroaniline (367-24-8) → 3-fluorobenzidine + 3,3'-difluorobiphenyl-4,4'-diamine (448-97-5) + p,p'-diaminobiphenyl (92-87-5)

Guidance literature:

With sodium hydroxide; sodium formate; cetyltrimethylammonim bromide; palladium on activated charcoal; In water; for 4h; Heating;

DOI:10.1021/ol070170h

Reference yield:

1,2-bis(2-fluorophenyl)hydrazine (454-21-7) → 3,3'-difluorobiphenyl-4,4'-diamine (448-97-5)

Guidance literature:

With hydrogenchloride;

Reference yield:

(Z)-1,2-bis(2-fluorophenyl)diazene 1-oxide (497-87-0) → 3,3'-difluorobiphenyl-4,4'-diamine (448-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium-amalgam; ethanol

2: aqueous HCl

With hydrogenchloride; sodium amalgam; ethanol;

upstream raw materials:

1,2-bis(2-fluorophenyl)hydrazine

4-bromo-2-fluoroaniline

(Z)-1,2-bis(2-fluorophenyl)diazene 1-oxide

2,2'-difluoroazobenzene

Refernces

• 1、 Favre-Besse, Franck-Cyril,Poirel, Odile,Bersot, Tiphaine,Kim-Grellier, Elodie,Daumas, Stephanie,El Mestikawy, Salah,Acher, Francine C.,Pietrancosta, Nicolas. "Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors". . p. 236 - 247. Retrieved 2014/04/17.