(3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID

Base Information

• Chemical Name: (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID
• CAS No.: 17768-36-4
• Molecular Formula: C12H18O3
• Molecular Weight: 210.273
• Hs Code.: 29162090
• Mol file: 17768-36-4.mol

Synonyms:1-Adamantaneaceticacid, 3-hydroxy- (8CI);1-Hydroxy-3-adamantaneacetic acid;3-Hydroxy-1-(carboxymethyl)adamantane;3-Hydroxy-1-adamantaneacetic acid;NSC252898;

Chemical Property of (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID

Chemical Property:

• Appearance/Colour: WHITE TO OFF-WHITE POWDER, CRYSTALS, CRYSTALLINE POWDER AND/OR CHUNKS
• Vapor Pressure: 3.6E-07mmHg at 25°C
• Melting Point: 125-129 °C
• Boiling Point: 375.3±15.0 °C at 760 mmHg
• PKA: 4.72±0.10(Predicted)
• Flash Point: 195.0±16.9 °C
• PSA: 57.53000
• Density: 1.3±0.1 g/cm³
• LogP: 1.79240
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

3-Hydroxy-1-adamantaneacetic Acid >97.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID

There total 13 articles about (3-HYDROXY-ADAMANTAN-1-YL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(carboxymethyl)adamantane-1-carboxylic acid (56531-58-9) → 2-(3-hydroxyadamantan-1-yl)acetic acid (17768-36-4)

Guidance literature:

With manganese(IV) oxide; sulfuric acid; at 25 - 30 ℃;

DOI:10.1134/S1070428016060051

Reference yield: 76.0%

(adamant-1-yl)-acetic acid (4942-47-6) → 2-(3-hydroxyadamantan-1-yl)acetic acid (17768-36-4)

Guidance literature:

With manganese(IV) oxide; sulfuric acid; at 25 - 30 ℃;

DOI:10.1134/S1070428016060051

Reference yield: 12.0%

(adamant-1-yl)-acetic acid (4942-47-6) → 2-oxo-1-tricyclo[3.3.1.13,7]decanacetic acid (16611-09-9) + 2-(3-hydroxyadamantan-1-yl)acetic acid (17768-36-4) + 4-oxoadamantane-1-acetic acid (81918-15-2) + C12H14O4

Guidance literature:

With sodium hydroxide; phosphate buffer; oxygen; iron(II) sulfate; In water; at 40 ℃; for 3h; Product distribution; investigation of the oxy-functionalization of adamantane-1-acetic acid;

upstream raw materials:

(3-bromo-1-adamantyl)acetic acid

(adamant-1-yl)-acetic acid

1,1-Dichloroethylene

adamantane

Refernces

• 1、 Ivleva,Gavrilova,Klimochkin, Yu. N.. "Synthesis of hydroxy derivatives from adamantanecarboxylic acids in the system MnO2–H2SO4". . p. 785 - 790. Retrieved 2016/07/30.
• 2、 Butenko, L. N.,Novakov, I. A.,Radchenko, S. S.,Kuznechikov, O. A.,Oglodina, T. Yu.,et al.. "SYNTHESIS OF 2,2'-(ADAMANTYLENE-1,3)-DIETHANOIC ACIDS". . p. 1244 - 1246. Retrieved 2007/10/02.