Levopropylhexedrine

Base Information

• Chemical Name: Levopropylhexedrine
• CAS No.: 6192-97-8
• Molecular Formula: C10H21N
• Molecular Weight: 155.283
• European Community (EC) Number: 228-245-0
• UNII: 4R3L4TYV09
• DSSTox Substance ID: DTXSID801024267
• Nikkaji Number: J215.792F
• Wikipedia: Levopropylhexedrine
• Wikidata: Q15409406
• NCI Thesaurus Code: C83883
• ChEMBL ID: CHEMBL2105014
• Mol file: 6192-97-8.mol

Synonyms:Levopropylhexedrine;l-propylhexedrine;Eventin;Levopropylhexedrine [INN];Levopropilhexedrina;Levopropylhexedrinum;(-)-propylhexedrine;6192-97-8;Propylhexedrine l-form;Propylhexedrine, (s)-;UNII-4R3L4TYV09;4R3L4TYV09;Levopropylhexedrinum [INN-Latin];Levopropilhexedrina [INN-Spanish];EINECS 228-245-0;(-)-N,alpha-Dimethylcyclohexaneethylamine;Levopropylhexedrin;SCHEMBL161851;CHEMBL2105014;DTXSID801024267;PROPYLHEXEDRINE L-FORM [MI];LEVOPROPYLHEXEDRINE [WHO-DD];AKOS006271447;N,I+/--Dimethylcyclo-hexan ethylamine;L-1-CYCLOHEXYL-2-METHYLAMINOPROPANE;[(2S)-1-cyclohexylpropan-2-yl](methyl)amine;Cyclohexaneethanamine, N,.alpha.-dimethyl-, (S)-;Cyclohexaneethylamine, N,.alpha.-dimethyl-, (-)-;(-)-N,.ALPHA.-DIMETHYLCYCLOHEXANEETHYLAMINE;Q15409406;CYCLOHEXANEETHANAMINE, N,.ALPHA.-DIMETHYL-, (.ALPHA.S)-

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Chemical Property of Levopropylhexedrine

Chemical Property:

• Vapor Pressure: 0.256mmHg at 25°C
• Refractive Index: 1.447
• Boiling Point: 205 °C at 760 mmHg
• PKA: 10.78±0.10(Predicted)
• Flash Point: 59.1 °C
• PSA: 12.03000
• Density: 0.833 g/cm³
• LogP: 2.95560
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 155.167399674
• Heavy Atom Count: 11
• Complexity: 95

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1CCCCC1)NC
• Isomeric SMILES: C[C@@H](CC1CCCCC1)NC

Technology Process of Levopropylhexedrine

There total 7 articles about Levopropylhexedrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

S-methamphetamine hydrochloride (51-57-0,4298-16-2) → (S)-1-cyclohexyl-N-methylpropan-2-amine (6192-97-8,3595-11-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; at 55 ℃; for 6h; under 3878.71 - 4137.29 Torr;

DOI:10.1021/op400313y

Reference yield:

Methamphetamin (537-46-2) → (S)-1-cyclohexyl-N-methylpropan-2-amine (6192-97-8,3595-11-7)

Guidance literature:

With acetic acid; platinum; Hydrogenation;

DOI:10.1021/ja01197a039

Reference yield:

Novafed (345-78-8) → (S)-1-cyclohexyl-N-methylpropan-2-amine (6192-97-8,3595-11-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / water / 12 h / 20 °C

2: Raney Ni / isopropyl alcohol / 50 - 55 °C / Autoclave

3: hydrogenchloride / ethyl acetate / 20 h / 0 - 20 °C / Large scale

4: 5%-palladium/activated carbon; hydrogen / 6 h / 55 °C / 3878.71 - 4137.29 Torr

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; sodium hydrogencarbonate; In water; ethyl acetate; isopropyl alcohol;

DOI:10.1021/op400313y

upstream raw materials:

Methamphetamin

propylhexedrine

4-cyclohexyl-butan-2-one

S-methamphetamine hydrochloride

Downstream raw materials:

(S)-N-benzyl-1-cyclohexyl-N-methylpropan-2-amine hydrochloride

(S)-N-benzylpropylhexedrine

Refernces