Dexlofexidine

Base Information

• Chemical Name: Dexlofexidine
• CAS No.: 81447-79-2
• Molecular Formula: C11H12Cl2N2O
• Molecular Weight: 259.135
• Mol file: 81447-79-2.mol

Synonyms:2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline;(-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene;Lofexidina;Lofexidinum [INN-Latin];rac-lofexidine;rac-2-[1-(2,6-dichlorophenoxy)ethyl]-1,3-diazacyclopent-2-ene;Britlofex;Lofexidine;Lofexidinum;Lofexidine [INN:BAN];Lofexidina [INN-Spanish];

Chemical Property of Dexlofexidine

Chemical Property:

• PSA: 33.62000
• LogP: 2.52680

Purity/Quality:

98% ^*data from raw suppliers

(S)-Lofexidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-Lofexidine is the S-enantiomer of Lofexidine,a 2-Adrenoceptor agonist related structurally to Clonidine.(S)-Lofexidine is Used in treatment of opioid withdrawal symptoms; antihypertensive.

Technology Process of Dexlofexidine

There total 16 articles about Dexlofexidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(±)ethyl 2-(2,6-dichlorophenoxy)propionate (344559-34-8,86981-78-4) + ethylenediamine (107-15-3,85404-18-8) → lofexidine (73372-53-9,81447-78-1,81447-79-2,31036-80-3)

Guidance literature:

ethylenediamine; With titanium(IV) isopropylate; In toluene; at 20 ℃; for 1h; Inert atmosphere;

(±)ethyl 2-(2,6-dichlorophenoxy)propionate; In toluene; at 110 ℃; for 18h; Time; Inert atmosphere;

Reference yield: 60.0%

2-(2,6-dichlorophenoxy)-propionitrile (78302-27-9,86981-81-9,87789-43-3) + ethylenediamine (107-15-3,85404-18-8) → lofexidine (73372-53-9,81447-78-1,81447-79-2,31036-80-3)

Guidance literature:

With carbon disulfide; ammonia; In toluene; Heating;

Reference yield: 30.0%

C10H10Cl2O3 (1112401-07-6) + ethylenediamine (107-15-3,85404-18-8) → (-)-2-(2,6-dichlorophenoxy)-propionic acid-N-(2-aminoethyl)-amide (344443-16-9) + lofexidine (73372-53-9,81447-78-1,81447-79-2,31036-80-3)

Guidance literature:

at 0 ℃; for 8h; Time; Mechanism;

DOI:10.1021/op8002689

upstream raw materials:

2-(2,6-dichlorophenoxy)-propionitrile

ethylenediamine

2,6-Dichlorophenol

C₁₀H₁₀Cl₂O₃

Downstream raw materials:

(-)-Lofexidine

(+)-Lofexidine hydrochloride

lofexidine hydrochloride

Refernces

• 1、 -. "PROCESS FOR THE SYNTHESIS OF LOFEXIDINE". . . Retrieved 2021/10/22.
• 2、 -. "LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS". Page/Page column 10. . Retrieved 2010/04/03.