8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline

Base Information

• Chemical Name: 8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline
• CAS No.: 1355340-87-2
• Molecular Formula: C₂₂H₂₄ClN₃O₃
• Molecular Weight: 413.904
• Mol file: 1355340-87-2.mol

Synonyms:8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline

Chemical Property of 8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline

There total 1 articles about 8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4-Chlorophenyl chloroformate (7693-45-0) + primaquine diphosphate (63-45-6) → 8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline (1355340-87-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 2h;

DOI:10.1016/j.bmc.2011.11.059

Reference yield:

8-[4-(4-chlorophenoxycarbonyl)amino-1-methylbutylamino]-6-methoxyquinoline (1355340-87-2) → Primaquine (90-34-6,57152-58-6)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 37 ℃; Kinetics; aq. borate buffer;

DOI:10.1016/j.bmc.2011.11.059

upstream raw materials:

4-Chlorophenyl chloroformate

primaquine diphosphate

Downstream raw materials:

Primaquine

Refernces