Decaethylene Glycol Monomethyl Ether

Base Information

• Chemical Name: Decaethylene Glycol Monomethyl Ether
• CAS No.: 27425-92-9
• Molecular Formula: C21H44O11
• Molecular Weight: 472.574
• Hs Code.: 2909499000
• ChEMBL ID: CHEMBL4293235
• DSSTox Substance ID: DTXSID30561598
• Nikkaji Number: J97.017D
• Wikidata: Q72461559
• Mol file: 27425-92-9.mol

Synonyms:27425-92-9;Decaethylene Glycol Monomethyl Ether;m-PEG10-alcohol;2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-ol;mPEG10-OH;2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol;MFCD06797087;C21H44O11;Methyl-PEG10-alcohol;SCHEMBL829171;CHEMBL4293235;DTXSID30561598;BCP11270;AKOS022174860;AS-69287;BP-22072;SY054596;HY-141218;CS-0114726;D2903;NS00076624;C70272;A876941;J-520209;m-PEG10-alcohol (Decaethylene glycol monomethyl ether)

Chemical Property of Decaethylene Glycol Monomethyl Ether

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 19 °C
• Refractive Index: 1.455
• Boiling Point: 524.316 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 270.897 °C
• PSA: 112.53000
• Density: 1.083 g/cm³
• LogP: -0.22550
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 29
• Exact Mass: 472.28836222
• Heavy Atom Count: 32
• Complexity: 324

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
• Description: m-PEG10-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-ol is used as a reactant in the synthesis of functional vinyl ethers and radical alternating copolymers with chlorotrifluoroethylene.

Technology Process of Decaethylene Glycol Monomethyl Ether

There total 10 articles about Decaethylene Glycol Monomethyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

hexaethylene glycol monomethyl ether (23601-40-3,95507-80-5) + 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide → O-methyl-decaethylene glycol (27425-92-9)

Guidance literature:

hexaethylene glycol monomethyl ether; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide; In tetrahydrofuran; mineral oil; at 20 ℃; for 12h; Inert atmosphere;

With sulfuric acid; water; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2018.10.009

Reference yield: 45.0%

methyl hexaethylene glycol chloride (113694-55-6) + Tetraethylene glycol (112-60-7) → O-methyl-decaethylene glycol (27425-92-9)

Guidance literature:

With potassium tert-butylate; calcium chloride;

Reference yield:

20-methoxy-1-(methylsulfonyl)oxy-3,6,9,12,15,18-hexaoxaeicosane (477775-57-8) → O-methyl-decaethylene glycol (27425-92-9)

Guidance literature:

upstream raw materials:

methyl hexaethylene glycol chloride

Tetraethylene glycol

20-methoxy-1-(methylsulfonyl)oxy-3,6,9,12,15,18-hexaoxaeicosane

hexaethylene glycol monomethyl ether

Downstream raw materials:

3,6,9,12,15,18,21,24,27,30,33-undecaoxatetratriacontanoic acid

Refernces

• 1、 Deng, Tao,Mao, Xianglan,Li, Yu,Bo, Shaowei,Yang, Zhigang,Jiang, Zhong-Xing. "Monodisperse oligoethylene glycols modified Propofol prodrugs". . p. 3502 - 3505. Retrieved 2018/10/15.
• 2、 -. "Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith". . . Retrieved 2008/06/13.